4-氨基-2-甲氧基嘧啶合成路线 （共 12 条）
反应条件
sodium methylate in methanol
参考文献
Glaxosmithkline LLC; Aubart, Kelly M.; Benowitz, Andrew B.; Fang, Yuhong; Hoffman, James; Karpinski, Joseph M.; Knox, Andrew Nicholson; Liao, Xiangmin; Qin, Donghui; Shi, Dongchuan; Spletstoser, Jared T.
Patent: US2013/345120 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
sodium methylate in water
反应条件
in methanol 6 h; Heating / reflux;
参考文献
WO2005/49616 A1, ;
Page/Page column 80 ;
WO 2005/049616 A1
反应条件
ammonia; water Erwaermen des Reaktionsprodukts mit methanol.Natriummethylat;
参考文献
Journal of the American Chemical Society, , vol. 52, p. 1152,1156; vgl. H 24 80
Journal of the American Chemical Society, , vol. 56, p. 190,192
Zhurnal Obshchei Khimii, , vol. 27, p. 2113;engl.Ausg. S.2170
反应条件
caesium carbonate in N,N-dimethyl-formamide T=90°C; 3 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 14 p. 2299 - 2302
反应条件
2 h; Heating / reflux;
参考文献
US2008/255172 A1, ;
Page/Page column 65 ;
反应条件
ammonia 1) methanol; Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 149 - 153
参考文献
Kimura, Junji; Yagi, Kentaro; Suzuki, Hideyuki; Mitsunobu, Oyo
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 12 p. 3670 - 3677
反应条件
copper dichloride; isopentyl nitrite in acetonitrile T=82°C; 24 h; chemoselective reaction;
参考文献
Xu, Chunyan; Cheng, Chuanjie; Liu, Hongtao; Liu, Bo
Letters in Organic Chemistry, 2011 , vol. 8, # 8 p. 545 - 548
反应条件
hydrogenchloride; water; copper(I) bromide; sodium nitrite in acetonitrile 6 h; Reflux; chemoselective reaction;
参考文献
Xu, Chunyan; Cheng, Chuanjie; Liu, Hongtao; Liu, Bo
Letters in Organic Chemistry, 2011 , vol. 8, # 8 p. 545 - 548
