1-甲基-4-苯基乙炔苯合成路线 （共 165 条）
反应条件
1: 2N NaOH / tetrahydrofuran / 1 h / 20 °C 2: 51 percent / toluene; tetrahydrofuran / -45 - 20 °C View Scheme
参考文献
Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Wang, Mingyi
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7526 - 7529
反应条件
1: n-BuLi, HMDS / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C to r.t., 30 min 2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -60 - 0 °C View Scheme
参考文献
Koebrich,G. et al.
Chemische Berichte, 1967 , vol. 100, p. 961 - 973
反应条件
potassium carbonate; palladium dichloride in methanol; water; toluene T=80°C; Suzuki coupling; 8 h;
参考文献
Shi, Yu; Li, Xiaoyu; Liu, Jianhui; Jiang, Wenfeng; Sun, Licheng
Applied Organometallic Chemistry, 2011 , vol. 25, # 7 p. 514 - 520
反应条件
FeCl3·6H2O; silver carbonate in dimethyl sulfoxide T=130°C;
参考文献
You, Xiu L.; Xu, Lai; Hu, Tao
Letters in Organic Chemistry, 2012 , vol. 9, # 4 p. 300 - 304
反应条件
copper(l) chloride; bis(dibenzylideneacetone)-palladium(0); tris(p-fluoro phenyl)phosphine in N,N-dimethyl-formamide T=100°C; sila-Sonogashira-Hagihara cross-coupling; 24 h; Inert atmosphere;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
1: 44 percent / t-BuOK / 1.) THF, -10 deg C, 10 min, 2.) THF, 25 deg C, 18 h 2: 15 percent / t-BuOK / dimethylformamide / 85 °C View Scheme
参考文献
Katritzky, Alan R.; Gordeev, Mikhail F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 11 p. 1295 - 1298
反应条件
in 1-methyl-pyrrolidin-2-one T=80°C; 14 h;
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
1: pyrrolidine; 4-laurylbenzenesulfonic acid sodium salt; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; Najera palladacycle I; water / 0.5 h / 130 °C / |Microwave irradiation; |Sealed tube; |Green chemistry 2: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; N-hexadecyl-N,N,N-trimethylammonium bromide; di-μ-chlorobis[5-hydroxy-2-[1-(hydroxyimino)ethyl]phenyl]palladium(II) dimer; triethylamine / water / 0.5 h / 130 °C / |Microwave irradiation; |Green chemistry View Scheme
参考文献
Buxaderas, Eduardo; Alonso, Diego A.; Najera, Carmen
European Journal of Organic Chemistry, 2013 , # 26 p. 5864 - 5870
参考文献
Mcewen,W.E.; Guzikowski,A.P.
Journal of Fluorine Chemistry, 1984 , vol. 25, p. 169
反应条件
in neat (no solvent) T=110°C; 6 h; Yield given. Yields of byproduct given;
参考文献
Akiba, Kin-ya; Okinaka, Takaaki; Nakatani, Masayuki; Yamamoto, Yohsuke
Tetrahedron Letters, 1987 , vol. 28, # 29 p. 3367 - 3368
