3-羟基-3-甲基-1-对甲苯磺酰基吡咯烷-2-甲酸乙酯合成路线 （共 8 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C;
参考文献
SEPRACOR INC.
Patent: US2005/143443 A1, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
potassium tert-butylate in tetrahydrofuran; tert-butyl alcohol T=20°C; 48 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 11 p. 3219 - 3223
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; 72 h; Cooling with ice;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; HORIUCHI, Yoshihiro; FUJIWARA, Hiroaki; SUDA, Hitoshi; SASAKI, Izumi; IWATA, Mitsutaka; SAWAMURA, Kiyoto
Patent: EP2612848 A1, 2013 ;
Location in patent: Paragraph 0374; 0375; 0377 ;
反应条件
potassium tert-butylate in diethyl ether; tert-butyl alcohol T=0 - 23°C; 73 h;
参考文献
Makino, Kazuishi; Suzuki, Tatsuya; Hamada, Yasumasa
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 9 p. 1649 - 1653
反应条件
1: 69 percent / conc. H2SO4 / toluene / 5 h / Heating 2: 1,8-diazabicyclo<5.4.0>undec-7-ene / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 28, # 7 p. 1671 - 1676
反应条件
1: pyridine / dichloromethane / 20 °C / |Cooling with ice 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 72 h / 20 °C / |Cooling with ice View Scheme
反应条件
sodium ethanolate in ethanol T=20°C; 5 h;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; TRUSTEES OF BOSTON UNIVERSITY
Patent: WO2009/23272 A1, 2009 ;
Location in patent: Page/Page column 36 ;
反应条件
pyridine; trichlorophosphate T=20°C;
参考文献
SEPRACOR INC.
Patent: US2005/143443 A1, 2005 ;
Location in patent: Page/Page column 39-40 ;
