lithium diisopropyl amide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=-78°C;

2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene T=80°C; 1.5 h;

1: cis-3-hexene-1-ol 0.5 h; Inert atmosphereMolecular sieve; 2: carbon monoxide With dicarbonylacetylacetonato rhodium (I); Ph2P(OMe); hydrogen; lithium chloride in toluene T=40°C; P=15001.5 Torr; 20 h; Molecular sieve; 3: With aluminum oxide; sodium acetate; pyridinium chlorochromate in dichloromethane T=20°C; 12 h; regioselective reaction;

1: trans-3-hexene-1-ol 0.5 h; Inert atmosphereMolecular sieve; 2: carbon monoxide With dicarbonylacetylacetonato rhodium (I); Ph2P(OMe); hydrogen; lithium chloride in toluene T=40°C; P=15001.5 Torr; 20 h; Molecular sieve; 3: With aluminum oxide; sodium acetate; pyridinium chlorochromate in dichloromethane T=20°C; 12 h; regioselective reaction;

10 Pd/C; hydrogen in methanol P=1500.15 Torr; Inert atmosphere;

1: benzene / Ambient temperature 2: 94 percent / pyridine / benzene / 1 h 3: 74 percent / n-Bu3SnH, AIBN / benzene / Heating View Scheme

1: 94 percent / pyridine / benzene / 1 h 2: 74 percent / n-Bu3SnH, AIBN / benzene / Heating View Scheme

R.T.S.A in toluene

1: 72 percent / LHMDS / tetrahydrofuran / 1 h / -70 °C 2: 91 percent / 30percent H2O2 / 0.33 h / 0 deg C to r.t. View Scheme