2-嘧啶胺,4-咪唑并1,2-a吡啶-3-基-合成路线 （共 5 条）
反应条件
sodium methylate in methanol; butan-1-ol 60 h; Heating / reflux;
参考文献
AstraZeneca AB
Patent: EP1214318 B1, 2003 ;
Location in patent: Page/Page column 36 ;
反应条件
hydrogenchloride; sodium methylate in methanol; butan-1-ol 48 h; Heating;
参考文献
Byth, Kate F.; Culshaw, Janet D.; Green, Stephen; Oakes, Sandra E.; Thomas, Andrew P.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2245 - 2248
反应条件
1: 44 percent / diethyl ether; tetrahydrofuran / 12 h / Heating 2: 72 h / Heating 3: NaOMe / butan-1-ol / 85 °C 4: 67 percent / HCl; NaOMe / butan-1-ol; methanol / 48 h / Heating View Scheme
参考文献
Byth, Kate F.; Culshaw, Janet D.; Green, Stephen; Oakes, Sandra E.; Thomas, Andrew P.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2245 - 2248
反应条件
1: 72 h / Heating 2: NaOMe / butan-1-ol / 85 °C 3: 67 percent / HCl; NaOMe / butan-1-ol; methanol / 48 h / Heating View Scheme
参考文献
Byth, Kate F.; Culshaw, Janet D.; Green, Stephen; Oakes, Sandra E.; Thomas, Andrew P.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2245 - 2248
反应条件
1: N-chlorosuccinimine
2: NaNO2; AcOH / 3 h / 60 °C
3: POCl3; PCl5 / 24 h / Heating
View Scheme
参考文献
Byth, Kate F.; Culshaw, Janet D.; Green, Stephen; Oakes, Sandra E.; Thomas, Andrew P.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2245 - 2248
