3-硝基-5-(三氟甲基)苯甲酸合成路线 （共 18 条）
反应条件
sulfuric acid; nitric acid T=0 - 35°C; 4 h;
参考文献
Shirai, Junya; Morimoto, Shinji; Sugiyama, Hideyuki; Sakauchi, Nobuki; Yoshikawa, Takeshi
Patent: US2008/275085 A1, 2008 ;
Location in patent: Page/Page column 45 ;
US 20080275085 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=760.051 Torr; 7 h;
参考文献
Shirai, Junya; Morimoto, Shinji; Sugiyama, Hideyuki; Sakauchi, Nobuki; Yoshikawa, Takeshi
Patent: US2008/275085 A1, 2008 ;
Location in patent: Page/Page column 45 ;
US 20080275085 A1
反应条件
palladium monocarbide in ethanol
参考文献
G.D. SEARLE and CO.
Patent: EP889875 B1, 2001 ;
Title/Abstract Full Text Show Details
G.D. SEARLE and CO.
Patent: EP889877 B1, 2001 ;
反应条件
thionyl chloride; ammonia; trichlorophosphate in methanol; n-heptane; ethyl acetate; N,N-dimethyl-formamide; toluene
参考文献
Noro Nordisk A/S
Patent: US6503949 B1, 2003 ;
US 6503949 B1
反应条件
1.1: acetyl chloride / ethyl acetate; methanol / 6.67 h / 0 °C / Reflux 2.1: hydrogen / palladium 10 on activated carbon / ethanol / 1 h / 20 °C / 2068.65 Torr 3.1: tert.-butylnitrite / acetonitrile / 0.25 h / 20 °C 3.2: 20 °C 4.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 4 h / -78 °C 5.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C View Scheme
反应条件
(i) SOCl2, (ii) /BRN= 102549/; Multistep reaction;
参考文献
Welch,D.E. et al.
Journal of Medicinal Chemistry, 1969 , vol. 12, # 2 p. 299 - 303
反应条件
sulfuric acid Reflux;
参考文献
EXELIXIS, INC.; ANAND, Neel, Kumar; BROWN, S., David; TESFAI, Zerom; ZAHARIA, Cristiana, A.
Patent: WO2012/37132 A1, 2012 ;
Location in patent: Page/Page column 47 ;
WO 2012/037132 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 15 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/4749 A1, 2007 ;
Location in patent: Page/Page column 125 ;
WO 2007/004749 A1
反应条件
sulfuric acid in methanol; water
参考文献
Meiji Seika Kaisha, Ltd.
Patent: EP1229024 A1, 2002 ;
反应条件
1: (COCl)2, DMF / CH2Cl2 / 18 h 2: NH4OH / tetrahydrofuran / 18 h View Scheme
参考文献
Sullivan, Robert W.; Bigam, Colin G.; Erdman, Paul E.; Palanki, Moorthy S. S.; Anderson, David W.; Goldman, Mark E.; Ransone, Lynn J.; Suto, Mark J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 413 - 419
