反应条件
1: 1.) diisopropylethylamine, dibutylboryl triflate (n-Bu2BOTf), 2.) N-bromosuccinimide (NBS) / 1.) CH2Cl2, a.) -78 deg C, 15 min, b.) 0 deg C, 1 h, 2.) -78 deg C, 1.25 h 2: tetramethylguanidinium azide (TMGA) / CH2Cl2 / 3 h / 0 °C 3: 96 percent / lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 0 °C 4: 92 percent / H2 / 10percent Pd/C / H2O; acetic acid / 4 h / 760 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 10 p. 4011 - 4030
