2,4-双(三氟甲基)溴苯合成路线 （共 6 条）
反应条件
boron tribromide in dichloromethane T=-78 - 25°C; 5 h;
参考文献
WO2005/80340 A1, ;
Page/Page column 57 ;
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-75°C; 2 h; 2: With carbon tetrabromide in tetrahydrofuran; hexane; dichloromethane T=-75 - 25°C;
参考文献
Leconte, Stephane; Ruzziconi, Renzo
Journal of Fluorine Chemistry, 2002 , vol. 117, # 2 p. 167 - 172
反应条件
bromine; lithium in diethyl ether
参考文献
Bulletin of the Chemical Society of Japan, , vol. 61, # 5 p. 1625 - 1632
反应条件
1: 4-bromo-1,3-bis-(trifluoromethyl)-benzene With magnesium in diethyl ether 2: oxalic acid diethyl ester in diethyl ether T=-78°C;
参考文献
Hewawasam, Piyasena; Erway, Matthew; Thalody, George; Weiner, Harvey; Boissard, Christopher G.; Gribkoff, Valentin K.; Meanwell, Nicholas A.; Lodge, Nicholas; Starrett, Jr, John E.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1117 - 1120
反应条件
1: 4-bromo-1,3-bis-(trifluoromethyl)-benzene With isopropylmagnesium chloride in tetrahydrofuran T=-10°C; 2: boric acid trimethyl ester in tetrahydrofuran T=-10°C; 3: With hydrogenchloride in tetrahydrofuran; water T=25°C; 1.5 - 2.5 h;
参考文献
Gilead Sciences, Inc.; K.U. Leuven Research and Development; Gerhard Puerstinger
Patent: US2009/36460 A1, 2009 ;
Location in patent: Page/Page column 7; 8 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; triphenylphosphine in toluene
T=25 - 80°C; Sonogashira coupling; 16.0833 h; Inert atmosphere;
参考文献
Severin, Rene; Reimer, Jessica; Doye, Sven
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3518 - 3521
