1,4-二溴-2,5-二氟苯合成路线 （共 14 条）
反应条件
bromine in hexane; dichloromethane
参考文献
Zhurnal Obshchei Khimii, , vol. 29, p. 1593; engl. Ausg. S. 1566
Journal of the American Chemical Society, , vol. 73, p. 153
Journal of the American Chemical Society, , vol. 81, p. 94,98
参考文献
Zhurnal Obshchei Khimii, , vol. 29, p. engl. Ausg. S. 1566
Journal of the American Chemical Society, , vol. 73, p. 153
Journal of the American Chemical Society, , vol. 81, p. 94,98
反应条件
bromine in monofluoro-trichloromethane Irradiation; Further byproducts given. Yields of byproduct given;
参考文献
Bolton, Roger; Owen, Elaine S. E.
Journal of Fluorine Chemistry, 1990 , vol. 46, # 3 p. 393 - 406
反应条件
1: 1.4-dibromo-2,5-difluorobenzene With n-butyllithium in diethyl ether; hexane T=-78°C; 0.0333333 h; Inert atmosphere; 2: carbon dioxide in diethyl ether; hexane T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride in diethyl ether; hexane; water Inert atmosphere;
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in N,N-dimethyl-formamide T=80°C; Condensation; 15 h;
参考文献
Iovine; Kellett; Redmore; Therien
Journal of the American Chemical Society, 2000 , vol. 122, # 36 p. 8717 - 8727
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in N,N-dimethyl-formamide T=80°C; 24 h;
参考文献
Lemonnier, Jean-Francois; Guenee, Laure; Beuchat, Cesar; Wesolowski, Tomasz A.; Mukherjee, Prasun; Waldeck, David H.; Gogick, Kristy A.; Petoud, Stephane; Piguet, Claude
Journal of the American Chemical Society, 2011 , vol. 133, # 40 p. 16219 - 16234
反应条件
1.1: n-butyllithium / diethyl ether; hexane / 0.03 h / -78 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 1.3: |Inert atmosphere 2.1: thionyl chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C 3.1: ammonium hydroxide / chloroform / 0.5 h / 5 °C 4.1: trichlorophosphate / 2 h / 80 °C View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
1: 1.4-dibromo-2,5-difluorobenzene With n-butyllithium in toluene T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in toluene T=-78 - 20°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald J.
Patent: WO2013/74641 A1, 2013 ;
Location in patent: Paragraph 00350 ;
反应条件
ammonium chloride in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
ASTRAZENECA AB
Patent: US2010/267723 A1, 2010 ;
