4(5)-羟甲基咪唑盐酸盐合成路线 （共 18 条）
参考文献
Lorente, Antonio; Espinosa, Juan Felix; Fernandez-Saiz, Misericordia; Lehn, Jean-Marie; Wilson, W. David; Zhong, Yi Yi
Tetrahedron Letters, 1996 , vol. 37, # 25 p. 4417 - 4420
反应条件
hydrogenchloride; sodium carbonate; sodium nitrite in water T=4°C; 1 h;
参考文献
Daninos, Sophie; Mourabit, Ali Al; Ahond, Alain; Zurita, Manuel Bedoya; Poupat, Christiane; Potier, Pierre
Bulletin de la Societe Chimique de France, 1994 , vol. 131, p. 590 - 599
反应条件
triethylamine in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: US2009/170907 A1, 2009 ;
Location in patent: Page/Page column 45 ;
反应条件
4-(N,N-dimethlyamino)pyridine; sodium carbonate in tetrahydrofuran; water
参考文献
Zeneca Limited
Patent: US5521179 A1, 1996 ;
反应条件
N-ethyl-N,N-diisopropylamine
T=120°C; 12 h;
参考文献
DR. REDDY'S LABORATORIES LTD.
Patent: WO2004/101531 A1, 2004 ;
Location in patent: Page 67 ;
反应条件
triethylamine in tetrahydrofuran
3 h; Heating;
参考文献
Kokosa, John M.; Szafasz, Richard A.; Tagupa, Eumar
Journal of Organic Chemistry, 1983 , vol. 48, # 20 p. 3605 - 3607
参考文献
Lee, Ving; Benkovic, Stephen J.; Baker, Stephen J.; Maples, Kirk R.; Akama, Tsutomu; Zhang, Yong-Kang; Singh, Rajeshwar; Sauro, Vittorio A.; Pandit, Chetan; Su, Zhuoyi; Yang, Zhixiang
Patent: US2005/70503 A1, 2005 ;
反应条件
sodium hydrogencarbonate in water; ethyl acetate
参考文献
Merrell Toraude et Compagnie
Patent: US4221914 A1, 1980 ;
