反应条件
1.1: 72 percent / Me3SiCl / diethyl ether; hexane / 6 h / -78 °C
2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
2.2: oxodiperoxymolybdenum(pyridine)-hexamethylphosphorictriamide / tetrahydrofuran / 3 h / -78 °C
3.1: LDA / tetrahydrofuran / 0.33 h / -78 °C
3.2: 85 percent / tetrahydrofuran; dimethylformamide / -78 - 20 °C
4.1: 99 percent / LiAlH4 / tetrahydrofuran / 5 - 20 °C
5.1: 94 percent / DABCO / CH2Cl2 / 20 °C
6.1: 99 percent / NaHCO3 / dimethylsulfoxide / 5 h / 60 °C
7.1: 92 percent / DIBALH / toluene / 2 h / -78 °C
8.1: NaH / tetrahydrofuran / 0 - 20 °C
8.2: 85 percent / tetrahydrofuran / 3 h / -78 °C
9.1: 97 percent / p-toluenesulfinic acid / [Pd(PPh3)4] / CH2Cl2 / 2 h / 20 °C
10.1: 93 percent / DMAP; EDC; Et3N / CH2Cl2 / 31 h / 0 - 20 °C
11.1: aq. TFA / CH2Cl2 / 0 - 20 °C
12.1: 77 percent / HATU; DIPEA / dimethylformamide / 1.5 h / 0 - 20 °C
13.1: (CH3O)3CH; PPTS / CH2Cl2 / 2 h / 20 °C
13.2: AcBr / CH2Cl2 / 4 h / 20 °C
13.3: 72 percent / KHCO3; (nBu)4NBr / 1,2-dimethoxy-ethane / 27 h / 40 °C
View Scheme
参考文献
Mast, Christian Alexander; Eissler, Stefan; Stoncius, Arvydas; Stammler, Hans-Georg; Neumann, Beate; Sewald, Norbert
Chemistry - A European Journal, 2005 , vol. 11, # 16 p. 4667 - 4677
