1-氯-3,4-二氢-2-萘甲醛合成路线 （共 13 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate in dichloromethane T=20°C; 2 h; 2: 3,4-dihydronaphthalene-1(2H)-one in dichloromethane T=20°C; 16 h;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/9582 A1, 2004 ;
Location in patent: Page 21-22 ;
WO 2004/009582 A1
反应条件
trichlorophosphate T=20 - 65°C; Vilsmeier-Haack reaction; 7 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 43, # 2 p. 389 - 394
反应条件
copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride T=80°C; Sonogashira coupling; 18 h;
参考文献
Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2003 , # 5 p. 717 - 722
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol 1 h;
参考文献
Ellingboe; Alessi; Dolak; Nguyen; Tomer; Guzzo; Bagli; McCaleb
Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1176 - 1183
反应条件
in water T=45°C; Suzuki coupling; 3 h;
参考文献
Hesse; Kirsch
Synthesis, 2001 , # 5 p. 755 - 758
反应条件
in water T=45°C; Suzuki coupling; 3 h;
参考文献
Hesse, Stephanie; Kirsch, Gilbert
Tetrahedron Letters, 2002 , vol. 43, # 7 p. 1213 - 1215
反应条件
1,4-diaza-bicyclo[2.2.2]octane T=50°C; Baylis-Hillman reaction; 12 h; Neat (no solvent)Sonication;
参考文献
Zhong, Weihui; Jiang, Lingbo; Guo, Baoming; Wu, Yaotiao; Hong, Lingjuan; Chen, Yanhui
Synthetic Communications, 2010 , vol. 40, # 16 p. 2441 - 2456
反应条件
1,4-diaza-bicyclo[2.2.2]octane; AlCl3, aluminium chloride T=20°C; Baylis-Hillman reaction; 24 h; Neat (no solvent);
参考文献
Zhong, Weihui; Chen, Yanhui; Wang, Guan
Journal of Chemical Research, 2010 , # 1 p. 44 - 49
反应条件
potassium hydroxide; ammonium acetate
1.) 20 deg C, 4 h, 2.) acetamide, reflux, 3 d; Yield given. Multistep reaction;
参考文献
Katritzky,A.R.; Manson,C.M.
Journal of the American Chemical Society, 1983 , vol. 105, p. 3279
反应条件
1: 87 percent / NaN3 / dimethylsulfoxide / 5 - 25 °C
2: 72 percent / CH2Cl2 / 24 h / Heating
View Scheme
参考文献
Sami, Md. Izhar; Kar, Gandhi K.; Ray, Jayanta K.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 186 - 188
