1: With potassium tert-butylate in tetrahydrofuran T=0°C; 2 h; 2: With water; ammonium chloride in tetrahydrofuran 3: With lithium hydroxide hydrate; water in dimethyl sulfoxide T=20 - 70°C;
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1