4-羟基-1,3-二甲基-1H-喹啉-2-酮合成路线 （共 15 条）
反应条件
titanium tetrachloride in dichloromethane T=20°C; 5 h; Inert atmosphere;
参考文献
Zikou, Lamprini C.; Igglessi-Markopoulou, Olga
Synthesis, 2008 , # 12 art. no. T17907SS, p. 1861 - 1866
参考文献
Dooley, Johnathon D.; Reddy Chidipudi, Suresh; Lam, Hon Wai
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10829 - 10836
反应条件
1: With phosphorous pentoxide; sulfuric acid T=20°C; 1 h; 2: With ammonium hydroxide in ethanol
参考文献
Rudolf, Ondrej; Mrkvicka, Vladimir; Lycka, Antonin; Rouchal, Michal; Klasek, Antonin
Helvetica Chimica Acta, 2012 , vol. 95, # 8 p. 1352 - 1372
反应条件
1: With AlCl3, aluminium chloride; sulfuric acid T=20°C; 1 h; 2: With ammonium hydroxide in ethanol
参考文献
Rudolf, Ondrej; Mrkvicka, Vladimir; Lycka, Antonin; Rouchal, Michal; Klasek, Antonin
Helvetica Chimica Acta, 2012 , vol. 95, # 8 p. 1352 - 1372
反应条件
potassium phosphate buffer; ethylenediaminetetraacetic acid T=30°C; pH=8.0; 12 h;
参考文献
Abe, Ikuro; Abe, Tsuyoshi; Wanibuchi, Kiyofumi; Noguchi, Hiroshi
Organic Letters, 2006 , vol. 8, # 26 p. 6063 - 6065
反应条件
phosphorous pentoxide; sulfuric acid; acetic acid T=20°C; 2.5 h;
参考文献
Rudolf, Ondrej; Mrkvicka, Vladimir; Lycka, Antonin; Rouchal, Michal; Klasek, Antonin
Helvetica Chimica Acta, 2012 , vol. 95, # 8 p. 1352 - 1372
反应条件
1: 99 percent / CH2Cl2 / 20 °C 2: 55 percent / Na2Te / tetrahydrofuran / -20 - 20 °C View Scheme
参考文献
Dittmer, Donald C.; Li, Qun; Avilov, Dimitry V.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4682 - 4686
反应条件
sulfuric acid T=120°C; 22 h;
参考文献
Bergman, Jan; Brynolf, Anna; Vuorinen, Eino
Tetrahedron, 1986 , vol. 42, # 13 p. 3689 - 3696
反应条件
1: 62 percent / pyridine / dioxane / Ambient temperature 2: 56 percent / 1.) C6H5MgBr / 1.) reflux, THF, 20 h; 2.) water, 4 degC; reaction of other anthranilonitriles 3: 30percent H2SO4 / 22 h / 120 °C View Scheme
参考文献
Bergman, Jan; Brynolf, Anna; Vuorinen, Eino
Tetrahedron, 1986 , vol. 42, # 13 p. 3689 - 3696
反应条件
1: 80 percent / KOtBu / N,N-dimethyl-acetamide / Heating 2: 62 percent / pyridine / dioxane / Ambient temperature 3: 56 percent / 1.) C6H5MgBr / 1.) reflux, THF, 20 h; 2.) water, 4 degC; reaction of other anthranilonitriles 4: 30percent H2SO4 / 22 h / 120 °C View Scheme
参考文献
Bergman, Jan; Brynolf, Anna; Vuorinen, Eino
Tetrahedron, 1986 , vol. 42, # 13 p. 3689 - 3696
