2-氯-6-甲氧基苯甲酸合成路线 （共 17 条）
反应条件
1: With potassium hydroxide; water; dihydrogen peroxide T=70 - 100°C; 26 h; 2: With sulfuric acid in acetonitrile T=30°C; 0.5 h; 3: With sodium nitrite in acetonitrile T=20°C; 16 h;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2006/77414 A1, 2006 ;
Location in patent: Page/Page column 165-166 ;
WO 2006/077414 A1
反应条件
1: With (E)-1,2-Bis(dimethylamino)-ethylen; sec.-butyllithium in tetrahydrofuran T=-78°C; 2 h; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran T=-78 - 20°C;
参考文献
Nguyen, Thi-Huu; Chau, Nguyet Trang Thanh; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3419 - 3429
反应条件
1: With tert.-butylnitrite; copper dichloride in acetonitrile 18.0833 h; Inert atmosphere; 2: With sodium hydroxide in water pH=~ 14; 3: With hydrogenchloride in water pH=~ 1;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/147165 A1, 2009 ;
Location in patent: Page/Page column 40 ;
WO 2009/147165 A1
反应条件
tetrabutylammomium bromide in N,N-dimethyl-formamide T=5°C; electrolysis (I=0.4 A); Yields of byproduct given;
参考文献
Heintz, Monique; Sock, Oumar; Saboureau, Christophe; Perichon, Jacques; Troupel, Michel
Tetrahedron, 1988 , vol. 44, # 6 p. 1631 - 1636
反应条件
1: thiophenol With potassium tert-butylate in ammonia liquid NH3; 2: methyl 6-chloro-2-methoxybenzoate With ammonia 2 h; UV-irradiation;
参考文献
Uranga, Jorge G.; Montanez, Juan P.; Santiago, Ana N.
Tetrahedron, 2012 , vol. 68, # 2 p. 584 - 589
反应条件
potassium hydroxide 3 h; Heating;
参考文献
Murakami; Watanabe; Otsuka; Iwata; Yamada; Yokoyama
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 8 p. 1287 - 1293
反应条件
1: Ca(OH)2, Na2CO3 / H2O 2: OH- 3: KMnO4 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 29, p. 2693 - 2698
反应条件
1: 95 percent / 25percent aq. TiCl3, AcOH / 0.15 h / Ambient temperature 2: 1.) aq. NaNO2, H2SO4 / 2.) 120 deg C, 1 h 3: 81 percent / K2CO3 / acetone / 3.5 h / Heating 4: 98 percent / 10percent aq. KOH / 3 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 8 p. 1287 - 1293
反应条件
1: 81 percent / K2CO3 / acetone / 3.5 h / Heating 2: 98 percent / 10percent aq. KOH / 3 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 8 p. 1287 - 1293
反应条件
1: 1.) aq. NaNO2, H2SO4 / 2.) 120 deg C, 1 h 2: 81 percent / K2CO3 / acetone / 3.5 h / Heating 3: 98 percent / 10percent aq. KOH / 3 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 8 p. 1287 - 1293
