4,6-二羟基-3-苯并呋喃酮合成路线 (共 13 条)
反应条件
hydrogenchloride; zinc(II) chloride in diethyl ether T=20 - 100°C;
参考文献
Wyeth
Patent: US2009/311217 A1, 2009 ;
Location in patent: Page/Page column 51 ;
US 20090311217 A1
反应条件
sodium acetate in methanol 2 h; Reflux;
参考文献
Lee, Chong-Yew; Chew, Eng-Hui; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2957 - 2971
反应条件
potassium carbonate in methanol 2 h; Ambient temperature;
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1.1: HCl; zinc chloride / dioxane 1.2: 28 percent / hydrochloric acid / 1 h / 100 °C 2.1: 71 percent / sodium methoxide / methanol / 2 h / Heating View Scheme
参考文献
Bolek, David; Guetschow, Michael
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1399 - 1403
反应条件
1: 100 percent / conc. H2SO4 / 0.5 h / Ambient temperature 2: 70 percent / NBS, benzoyl peroxide / CCl4 / 12 h / 140 °C 3: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr 4: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1: 70 percent / NBS, benzoyl peroxide / CCl4 / 12 h / 140 °C 2: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr 3: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr 2: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
hydrogenchloride; diethyl ether Erwaermen des Reaktionsprodukts mit Wasser;
参考文献
Slater; Stephen
Journal of the Chemical Society, 1920 , vol. 117, p. 314
参考文献
Balakrishna; Rao; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1949 , vol. <A> 29, p. 394,401
反应条件
hydrogenchloride in acetic acid T=20°C; 5 h;
参考文献
Nishida, Jun; Kawabata, Jun
Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 1 p. 193 - 202