甲基 1,3-苯并二恶唑-5-羧酸酯合成路线 （共 49 条）
反应条件
sodium hydride 1) DMF, 2) 25 deg C, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Cassels, Bruce K.; Radetski, Claudemir; Rezende, Marcos Caroli
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, # 10 p. 448 - 450
参考文献
Shriner; Kleiderer
Journal of the American Chemical Society, 1929 , vol. 51, p. 1269
Full Text Show Details
Mauthner
Journal fuer Praktische Chemie (Leipzig), vol. <2> 166, p. 322
反应条件
sodium methylate T=90°C;
参考文献
DYBLY AG; KEMPEN, Herman; BELLUS, Daniel; STAEHELIN, Barbara
Patent: WO2010/49466 A1, 2010 ;
Location in patent: Page/Page column 11 ;
反应条件
1: aqueous ethanol; hydrazine hydrate 2: pyridine 3: sodium carbonate; ethylene glycol / 155 °C View Scheme
参考文献
McFadyen; Stevens
Journal of the Chemical Society, 1936 , p. 584
反应条件
1: 1) NaH / 1) DMF, 2) 25 deg C, 12 h 2: SOCl2 / 1 h / Heating View Scheme
参考文献
Cassels, Bruce K.; Radetski, Claudemir; Rezende, Marcos Caroli
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, # 10 p. 448 - 450
反应条件
1: LiAlH4 / diethyl ether / 2 h / Ambient temperature 2: 105 mg / H2 / 5percent Pd-C / methanol / 2 h / Ambient temperature View Scheme
参考文献
Ikeya, Yukinobu; Taguchi, Heihachiro; Yoshioka, Itiro
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2893 - 2898
反应条件
1: nitric acid; tin(IV) chloride / dichloromethane / -70 °C 2: hydrogen / methanol / 20 °C 3: sodium methylate / methanol; N,N-dimethyl-formamide / 110 °C 4: trichlorophosphate / Reflux View Scheme
参考文献
Garofalo, Antonio; Goossens, Laurence; Baldeyrou, Brigitte; Lemoine, Amelie; Ravez, Severine; Six, Perrine; David-Cordonnier, Marie-Helene; Bonte, Jean-Paul; Depreux, Patrick; Lansiaux, Amelie; Goossens, Jean-Francois
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 8089 - 8103
反应条件
1: aqueous ammonia / 60 - 80 °C / im Rohr 2: alkaline alkali hypobromite solution View Scheme
参考文献
van Linge
Recueil des Travaux Chimiques des Pays-Bas, 1897 , vol. 16, p. 45
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, 0 deg C, 30 min; 2.) THF, -78 deg C -> RT 2: 5.9 percent / NaBH4 / ethanol / 3 h / Heating 3: 84.4 percent / NaH / dimethylformamide; various solvent(s) / 0.5 h / 50 °C View Scheme
参考文献
Buss, Antony D.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2307 - 2326
反应条件
aluminum tri-bromide in ethanethiol T=0°C; 1 h;
参考文献
Node, Manabu; Nishide, Kiyoharu; Fuji, Kaoru; Fujita, Eiichi
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4275 - 4277
