1-Boc-3-氨甲基氮杂环丁烷合成路线 （共 4 条）
反应条件
ammonia; hydrogen; nickel in methanol T=20°C; P=30400 Torr; 3.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 1 p. 94 - 104
反应条件
1: Et3N / ethyl acetate / 1 h / 0 °C 2: 57 percent / dimethylsulfoxide / 48 h / 130 °C 3: H2; NH3 / Raney Ni / methanol / 3.5 h / 20 °C / 30400 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 1 p. 94 - 104
反应条件
1: 57 percent / dimethylsulfoxide / 48 h / 130 °C 2: H2; NH3 / Raney Ni / methanol / 3.5 h / 20 °C / 30400 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 1 p. 94 - 104
反应条件
sodium tris(acetoxy)borohydride; acetic acid in methanol; water
T=20°C; 20 h;
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1702917 A1, 2006 ;
Location in patent: Page/Page column 37 ;
