4-(甲氧基羰基)环己基-1-羧酸合成路线 （共 6 条）
反应条件
water; Ba(OH)2 in methanol T=25°C; 12 h;
参考文献
MERCK SHARP and DOHME CORP.; BARR, Kenneth Jay; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; ZHANG, Dongshan
Patent: WO2014/28597 A2, 2014 ;
Location in patent: Page/Page column 54 ;
反应条件
5 rhodium-on-charcoal; hydrogen in 1,4-dioxane; methanol P=38002.6 Torr;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 6 p. 1564 - 1568
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: barium hydroxide octahydrate; water / methanol / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1752 - 1761
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; Fonderma in chloroform T=57°C; Barton Decarboxylation; 0.416667 h; Inert atmosphere; 2: in chloroform Barton Decarboxylation; 1.83333 h; Inert atmosphereIrradiation;
参考文献
Ko, Eun Jung; Williams, Craig M.; Savage, G. Paul; Tsanaktsidis, John
Organic Syntheses, 2012 , vol. 89, p. 471 - 479
反应条件
BH3*S(CH3)2 in tetrahydrofuran T=-78°C; 3.33333 h;
参考文献
US2012/165347 A1, ;
Page/Page column 43 ;
US 20120165347 A1
反应条件
1: BH3*S(CH3)2 / tetrahydrofuran / 3.33 h / -78 °C
2: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/165347 A1, 2012 ;
US 20120165347 A1
