3,3-二甲基-1-苯基甲基-4-羟基哌啶合成路线 (共 2 条)
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 19 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: EP1204660 B1, 2004 ;
Location in patent: Page 15 ;
反应条件
1: With dimethyl sulfoxide; trifluoroacetic anhydride in dichloromethane T=-78°C; 0.5 h; 2: (rac)-1-Benzyl-3,3-dimethyl-piperidin-4-ol in dichloromethane T=-78°C; 1 h; 3: With triethylamine in dichloromethane T=0°C; 2 h;
参考文献
ELI LILLY AND COMPANY
Patent: EP1204660 B1, 2004 ;
Location in patent: Page 15 ;