1-(哌啶-4-甲基)哌啶合成路线 （共 10 条）
反应条件
hydrogen; platinum(IV) oxide in hydrogen; acetic acid T=20°C; P=2250.23 Torr;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 75 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1.5 h; Heating / reflux; 2: With sodium hydroxide; water T=0°C;
参考文献
Nencini, Arianna; Castaldo, Cristiana; Comery, Thomas A.; Dunlop, John; Genesio, Eva; Ghiron, Chiara; Haydar, Simon; Maccari, Laura; Micco, Iolanda; Turlizzi, Elisa; Zanaletti, Riccardo; Zhang, Jean
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 401 - 418
参考文献
Astellas Pharma Inc.
Patent: WO2009/131246 A1, 2009 ;
Location in patent: Page/Page column 84 ;
反应条件
1: 100 percent / CH2Cl2 2: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2 3: NaCNBH3; CF3CH2OH; 3A sieves 4: 100 percent / CF3COOH / CH2Cl2 View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
1: 100 percent / ClCOCOCl; DMSO; Et3N / CH2Cl2 2: NaCNBH3; CF3CH2OH; 3A sieves 3: 100 percent / CF3COOH / CH2Cl2 View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
1: NaCNBH3; CF3CH2OH; 3A sieves 2: 100 percent / CF3COOH / CH2Cl2 View Scheme
参考文献
Ting, Pauline C; Lee, Joe F; Anthes, John C; Shih, Neng-Yang; Piwinski, John J
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 491 - 494
反应条件
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 6 h / 85 °C 2: hydrogenchloride; water / 0 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / |Reflux View Scheme
参考文献
Nencini, Arianna; Castaldo, Cristiana; Comery, Thomas A.; Dunlop, John; Genesio, Eva; Ghiron, Chiara; Haydar, Simon; Maccari, Laura; Micco, Iolanda; Turlizzi, Elisa; Zanaletti, Riccardo; Zhang, Jean
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 401 - 418
反应条件
1: hydrogenchloride; water / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / |Reflux View Scheme
参考文献
Nencini, Arianna; Castaldo, Cristiana; Comery, Thomas A.; Dunlop, John; Genesio, Eva; Ghiron, Chiara; Haydar, Simon; Maccari, Laura; Micco, Iolanda; Turlizzi, Elisa; Zanaletti, Riccardo; Zhang, Jean
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 401 - 418
反应条件
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 6 h / 85 °C 2: hydrogenchloride; water / 0 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / |Reflux View Scheme
参考文献
Nencini, Arianna; Castaldo, Cristiana; Comery, Thomas A.; Dunlop, John; Genesio, Eva; Ghiron, Chiara; Haydar, Simon; Maccari, Laura; Micco, Iolanda; Turlizzi, Elisa; Zanaletti, Riccardo; Zhang, Jean
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 401 - 418
反应条件
Suzuki-Miyaura Coupling;
参考文献
Nencini, Arianna; Castaldo, Cristiana; Comery, Thomas A.; Dunlop, John; Genesio, Eva; Ghiron, Chiara; Haydar, Simon; Maccari, Laura; Micco, Iolanda; Turlizzi, Elisa; Zanaletti, Riccardo; Zhang, Jean
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 401 - 418
