2-(4-溴苯基)-2-甲基丙烷-1-醇合成路线 （共 6 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
pfizer Inc
Patent: US2010/197591 A1, 2010 ;
Location in patent: Page/Page column 20 ;
US 20100197591 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; 3 h; 2: With water; sodium hydroxide in tetrahydrofuran
参考文献
SCHERING CORPORATION; SCOTT, Jack, D.; STAMFORD, Andrew, W.; GILBERT, Eric, J.; CUMMING, Jared, N.; ISERLOH, Ulrich; WANG, Lingyan; LI, Wei
Patent: WO2011/44187 A1, 2011 ;
Location in patent: Page/Page column 94 ;
WO 2011/044187 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-78°C; 3.75 h; 2: With hydrogenchloride; water in tetrahydrofuran
参考文献
PFIZER INC.; ASPNES, Gary, Erik; DOW, Robert, Lee; MUNCHHOF, Michael, John
Patent: WO2010/86820 A1, 2010 ;
Location in patent: Page/Page column 50 ;
WO 2010/086820 A1
反应条件
hydrogenchloride in methanol T=20°C; 2 h;
参考文献
PFIZER INC.; Bhattacharya, Samit; Cameron, Kimberly; Dowling, Matthew; Fernando, Dilinie; Ebner, David; Filipski, Kevin; Kung, Daniel; Lee, Esther; Smith, Aaron; Tu, Meihua
Patent: US2013/267493 A1, 2013 ;
Location in patent: Paragraph 0842 ;
反应条件
1: CCl4; iron; bromine 2: LiAlH4; diethyl ether View Scheme
参考文献
Heck; Winstein
Journal of the American Chemical Society, 1957 , vol. 79, p. 3432,3437
参考文献
Sterling Drug Inc.
Patent: US4308382 A1, 1981 ;
