2-(4-溴苯基)-2-甲基丙酸合成路线 （共 16 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
pfizer Inc
Patent: US2010/197591 A1, 2010 ;
Location in patent: Page/Page column 20 ;
US 20100197591 A1
反应条件
sulfuric acid; acetonitrile T=80 - 85°C; 16 - 18 h;
参考文献
Dawar, Pankaj; Raju, M. Bagavan; Ramakrishna, Ramesha Andagar
Synthetic Communications, 2014 , vol. 44, # 6 p. 836 - 846
反应条件
sulfuric acid Reflux; regioselective reaction;
参考文献
Dawar, Pankaj; Bhagavan Raju; Ramakrishna, Ramesha A.
Tetrahedron Letters, 2011 , vol. 52, # 33 p. 4262 - 4265
反应条件
1.1: sulfuric acid / toluene / 16 h / 63 - 67 °C / Industry scale 2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / toluene / 24 h / Reflux 2.2: 2 h / 25 - 35 °C View Scheme
参考文献
Divi's Laboratories Limited
Patent: EP2532644 A1, 2012 ;
反应条件
1: 2-(4-bromophenyl)-2-methylpropionic acid With phenyllithium in tetrahydrofuran; toluene T=-80°C; 0.0833333 h; Inert atmosphere; 2: With n-butyllithium in tetrahydrofuran; hexane; toluene 0.333333 h; Inert atmosphere; 3: trans-β-chloroacrylonitrile Further stages;
参考文献
Zificsak, Craig A.; Shen, Yi; Lisko, Joseph G.; Theroff, Jay P.; Lao, Xuegang; Bollt, Oana; Li, Xiufen; Dorsey, Bruce D.; Kuwada, Scott K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1850 - 1853
反应条件
1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere 1.2: 0.33 h 1.3: 0.25 h 2.1: acetic acid / water; methanol / 20 °C 2.2: 1 h View Scheme
参考文献
CEPHALON, INC.; UNIVERSITY OF HAWAII; UNIVERSITY OF UTAH RESEARCH FOUNDATION; DORSEY, Bruce; KUWADA, Scott K.; THEROFF, Jay P.; ZIFICSAK, Craig A.
Patent: WO2012/116151 A2, 2012 ;
WO 2012/116151 A2
