2-(4-溴苯基)-2-甲基丙酸合成路线 （共 16 条）
反应条件
1: With water; lithium hydroxide hydrate in 1,4-dioxane T=50°C; 5.5 h; 2: With hydrogenchloride in 1,4-dioxane; water
参考文献
pfizer Inc
Patent: US2010/197591 A1, 2010 ;
Location in patent: Page/Page column 16 ;
US 20100197591 A1
反应条件
1: With bromine; sodium carbonate in water T=25 - 30°C; pH=7; 2: With hydrogenchloride in water pH=1 - 2; Product distribution / selectivity;
参考文献
Divi's Laboratories Limited
Patent: EP2532644 A1, 2012 ;
Location in patent: Page/Page column 5 ;
反应条件
methanol; sodium hydroxide; water in tetrahydrofuran T=20°C; 16 h;
参考文献
US2006/149070 A1, ;
Page/Page column 31 ;
反应条件
potassium hydroxide in ethanol; water T=80 - 85°C; Hydrolysis; 18 h;
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
反应条件
hydrogenchloride in tetrahydrofuran
反应条件
1: (+/-)-α-(4-bromophenyl)propionic acid With lithium diisopropyl amide in tetrahydrofuran T=45°C; 1 h; Inert atmosphereCooling with ice; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 135, # 4 p. 1236 - 1239
反应条件
1.1: AlCl3, aluminium chloride / Industry scale 2.1: sodium hydrogencarbonate; bromine / water / 13 h / 25 - 35 °C / Industry scale 2.2: 0 - 10 °C / pH 5 View Scheme
参考文献
Helvetica Chimica Acta, , vol. 54, p. 868 - 897
反应条件
1: 2-(4-bromophenyl)-2-methylpropionic acid With sodium hydride in tetrahydrofuran T=25°C; deprotonation; 0.5 h; 2: With tert.-butyl lithium in tetrahydrofuran T=-72°C; Metallation; 0.916667 h; 3: 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde in tetrahydrofuran T=-72°C; Condensation; 2.5 h;
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
反应条件
1.1: sulfuric acid / toluene / 16 h / 63 - 67 °C / Industry scale 2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / toluene / 24 h / Reflux 2.2: 2 h / 25 - 35 °C 3.1: sodium hydroxide; water / methanol / 16 h / 70 - 75 °C 3.2: 16 h View Scheme
参考文献
Divi's Laboratories Limited
Patent: EP2532644 A1, 2012 ;
