2-(3-甲氧基苯基)-2-甲基丙酸甲酯合成路线 （共 9 条）
反应条件
tri-tert-butyl phosphine; LiN(Cy)2; bis(dibenzylideneacetone)-palladium(0) in toluene T=20°C; 24 h;
参考文献
Jorgensen, Morten; Lee, Sunwoo; Liu, Xiaoxiang; Wolkowski, Joanna P.; Hartwig, John F.
Journal of the American Chemical Society, 2002 , vol. 124, # 42 p. 12557 - 12565
参考文献
IRM LLC
Patent: WO2007/56497 A1, 2007 ;
Location in patent: Page/Page column 51-52 ;
WO 2007/056497 A1
反应条件
1: 2-methylpropanoic acid methyl ester With sodium hexamethyldisilazane in toluene T=20°C; 0.166667 h; Inert atmosphere; 2: 1-chloro-3-methoxy-benzene With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene T=100°C; 4 h; Inert atmosphere;
参考文献
Hama, Takuo; Hartwig, John F.
Organic Letters, 2008 , vol. 10, # 8 p. 1549 - 1552
反应条件
sulfuric acid in methanol
参考文献
Bratton, Larry D.; Cheng, Xue-Min; Erasga, Noe; Filzen, Gary F.; Geyer, Andrew G.; Lee, Chitase; Trivedi, Bharat K.; Unangst, Paul C.
Patent: US2004/209936 A1, 2004 ;
反应条件
1: 2-methylpropanoic acid methyl ester With n-butyllithium; N,N-dicyclohexylamine in hexane; toluene T=0 - 5°C; 0.833333 h; 2: 3-methoxybromobenzene With [P(t-Bu)3Pd(μ-Br)]2 in hexane; toluene T=0 - 20°C; 5 h; Inert atmosphere;
参考文献
Huang, David S.; DeLuca, Ryan J.; Hartwig, John. F.
Organic Syntheses, 2012 , vol. 88, p. 4 - 13
参考文献
Cheng, Xue-Min; Erasga, Noe; Filzen, Gary Frederick; Geyer, Andrew; Lee, Chitase; Trivedi, Bharat Kalidas
Patent: US2003/207924 A1, 2003 ;
反应条件
lithium aluminium tetrahydride
参考文献
Kuentzel,H. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 868 - 897
反应条件
1: With methanol; lithium hydroxide; water in tetrahydrofuran T=60°C; 7 h; 2: in water Acidic aqueous solution;
参考文献
WO2009/42694 A1, ;
Page/Page column 119 ;
WO 2009/042694 A1
反应条件
1: LiAlH4
2: SO3, Py, Et3N / dimethylsulfoxide
3: pentane / Irradiation
View Scheme
参考文献
Kuentzel,H. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 868 - 897
