2-氨基-3-(3-乙酰基-4-羟基苯基)丙酸合成路线 （共 7 条）
反应条件
aluminium trichloride in nitrobenzene T=100°C; 6 h;
参考文献
Reimann, Eberhard; Pflug, Thomas
Monatshefte fur Chemie, 1998 , vol. 129, # 2 p. 187 - 193
反应条件
1: 74 percent / SOCl2 / Heating 2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 5 p. 1585 - 1596
反应条件
1: 74 percent / SOCl2 / Heating 2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C 3: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C View Scheme
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
反应条件
thionyl chloride 8 h; Heating;
参考文献
Heinrich, Markus R.; Steglich, Wolfgang
Tetrahedron, 2003 , vol. 59, # 46 p. 9231 - 9237
反应条件
1: 74 percent / SOCl2 / Heating 2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C 3: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C 4: mCPBA / CH2Cl2 / 40 °C 5: 453 mg / NH3 / CH2Cl2; methanol / 1 h 6: 61 percent / K2CO3 / dimethylformamide / 6 h / 25 °C 7: H2 / Pd/C / CH2Cl2 8: aq. Na2CO3 / acetonitrile View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: 74 percent / SOCl2 / Heating 2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C 3: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C 4: mCPBA / CH2Cl2 / 40 °C 5: 453 mg / NH3 / CH2Cl2; methanol / 1 h 6: H2 / Pd/C / CH2Cl2 View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: 74 percent / SOCl2 / Heating
2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
3: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
4: mCPBA / CH2Cl2 / 40 °C
5: 453 mg / NH3 / CH2Cl2; methanol / 1 h
View Scheme
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
