3-(4-氯苯基)-丙腈合成路线 （共 15 条）
反应条件
1: pyridine / dimethylformamide; benzene 2: 70 percent / SmI2 / methanol; tetrahydrofuran / 4 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 30, # 11 p. 1879 - 1885
反应条件
aluminium trichloride T=140°C;
参考文献
Zhurnal Obshchei Khimii, , vol. 25, p. 292
Chem.Abstr., , # 1639
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 13 p. 3569 - 3573
反应条件
1: 76.9 percent / TFA / 6 h / 60 - 80 °C 2: 73.5 percent / Dowtherm A / 1 h / 120 - 130 °C 3: 92.2 percent / conc. HNO3 / acetic acid / 2 h / Ambient temperature 4: 1.) POCl3, 2.) PhNEt2 / 1.) 70 - 90 deg C, 2.) 70 - 90 deg C, 3 h 5: 88.1 percent / conc. aq. NH4OH / dioxane / 0.25 h / 60 °C 6: tin, conc. aq. HCl / dioxane / Heating 7: conc. HCl, NaNO2 / H2O / 1 h View Scheme
参考文献
Suzuki; Miwa; Aibara; Kanno; Takamori; Tsubokawa; Ryokawa; Tsukada; Isoda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 357 - 363
反应条件
sulfuric acid T=150°C;
参考文献
Grebenjuk; Zukerwanik
Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 292
Chem.Abstr., 1956 , # 1639
