(2R,3R)-(-)-1,4-双(二苯基膦基)-2,3-O-异亚丙基-2,3-丁二醇合成路线 （共 10 条）
反应条件
trichlorosilane in toluene T=70 - 80°C; 15 h;
参考文献
Brunner, H.; Zettlmeier, W.
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 3 p. 247 - 257
反应条件
in tetrahydrofuran; Carnea E-22 T=40 - 50°C; Inert atmosphere; Product distribution / selectivity;
参考文献
Arkema Inc.
Patent: US2010/234642 A1, 2010 ;
Location in patent: Page/Page column 13 ;
反应条件
1: 78 percent / Et3N / 1 h / 25 °C 2: 2.) DABCO / 1.) THF, 20 deg C, 12 h, 2.) toluene, 40 deg C, 4 h View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 28 p. 4523 - 4526
反应条件
1: 84 percent / LiAlH4 / diethyl ether / 3 h / 36 °C 2: 78 percent / Et3N / 1 h / 25 °C 3: 2.) DABCO / 1.) THF, 20 deg C, 12 h, 2.) toluene, 40 deg C, 4 h View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 28 p. 4523 - 4526
反应条件
in tetrahydrofuran; diethyl ether -60 deg C, 2 h; r.t.;
参考文献
Werz, Udo; Brune, Hans-Albert
Journal of Organometallic Chemistry, 1989 , vol. 363, p. 377 - 386
反应条件
1: 95 percent / LiCl / dimethylsulfoxide / 16 h / 55 - 60 °C 2: n-butyllithium View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 2995 - 2999
反应条件
1: 45 percent / I2 / 3.67 h / 150 - 160 °C 2: 68 percent / trichlorosilane / toluene / 15 h / 70 - 80 °C View Scheme
参考文献
Bulletin des Societes Chimiques Belges, , vol. 100, # 3 p. 247 - 257
反应条件
n-butyllithium Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 2995 - 2999
反应条件
1,4-diaza-bicyclo[2.2.2]octane 1.) THF, 20 deg C, 12 h, 2.) toluene, 40 deg C, 4 h; Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 34, # 28 p. 4523 - 4526
反应条件
toluene-4-sulfonic acid 3 h; Yield given;
参考文献
Tetrahedron: Asymmetry, , vol. 2, # 3 p. 173 - 174
