3-甲基-1-戊烯-4-炔-3-醇合成路线 （共 33 条）
反应条件
1: H2O, H2SO4 2: imidazole / dimethylformamide View Scheme
参考文献
Shibuya, Satoshi; Isobe, Minoru
Tetrahedron, 1998 , vol. 54, # 24 p. 6677 - 6698
反应条件
1: 81 percent / aq. H2SO3 / 2 h / 50 °C
2: Pd/Cu
3: 77 percent / KI / PdI2 / N,N-dimethyl-acetamide / 24 h / 100 °C
View Scheme
参考文献
Gabriele; Salerno; Lauria
Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 7687 - 7692
反应条件
(i) PCl3, Py, Et2O, (ii) /BRN= 1098229/; Multistep reaction;
参考文献
Angelov,Kh.M. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1979 , vol. 49, p. 1960 - 1963,1724 - 1727
反应条件
(i) PCl3, Py, Et2O, (ii) /BRN= 635639/; Multistep reaction;
参考文献
Angelov,Kh.M. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1979 , vol. 49, p. 1960 - 1963,1724 - 1727
反应条件
1: MgSO4, BF3*Et2O / 1 h / 5 °C
2: 1.) 1.5 M BuLi / 1.) THF/hexane, -30 deg C, 2.) THF/hexane, 2 h, room temperature
3: 97 percent / hydrogen / Lindlar-catalyst, 1,2-bis<(2-hydroxyethyl)thio>ethane / ethanol / 4 h / Ambient temperature
4: 13 percent / TsOH*H2O / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Soukup; Broger; Widmer
Helvetica Chimica Acta, 1989 , vol. 72, # 2 p. 370 - 376
反应条件
Lindlar's catalyst; Petroleum ether
Hydrogenation;
参考文献
Hoffmann-La Roche
Patent: US2760998 , 1952 ;
反应条件
hydrogen; palladium in ethanol
T=29.9°C; P=15001.2 Torr; different catalysts (group VIII);
参考文献
Sokolo'skii, D. V.; Zhubanova, L. K.; Omarkulov, T. O.; Sadykov, U. A.; Korolev, A. V.
Russian Journal of Physical Chemistry, 1990 , vol. 64, # 1 p. 43 - 46
Zhurnal Fizicheskoi Khimii, 1990 , vol. 64, # 1 p. 83 - 87
反应条件
pyridine; phosphorus tribromide in diethyl ether
T=-15 - 20°C;
参考文献
Gabriele, Bartolo; Salerno, Giuseppe; Fazio, Alessia
Journal of Organic Chemistry, 2003 , vol. 68, # 20 p. 7853 - 7861
反应条件
1: 81 percent / aq. H2SO3 / 2 h / 50 °C
View Scheme
参考文献
Gabriele; Salerno; Lauria
Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 7687 - 7692
反应条件
acid
Allylic Rearrangement;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: EP1167331 A2, 2002 ;
Location in patent: Scheme 2 ;
