7-溴-3,4-二氢萘-1(2H)-酮合成路线 （共 31 条）
反应条件
bromine; AlCl3, aluminium chloride T=80°C;
参考文献
WO2005/95326 A2, ;
Page/Page column 110-111 ;
WO 2005/095326 A2
参考文献
Mallory, Frank B.; Luzik, Eddie D.; Mallory, Clelia W.; Carroll, Patrick J.
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 366 - 370
反应条件
1: With AlCl3, aluminium chloride T=0 - 90°C; 0.916667 h; 2: With bromine T=90°C; 1 h;
参考文献
Baylor University
Patent: US2009/76076 A1, 2009 ;
Location in patent: Page/Page column 20 ;
US 20090076076 A1
反应条件
pivalaldehyde in toluene T=40°C; 0.5 h; Flow reactor;
参考文献
Chorghade, Rajeev; Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V.
Organic Letters, 2013 , vol. 15, # 22 p. 5698 - 5701
反应条件
1: 82 percent / KOH; hydrazine monohydrate / triethylene glycol / 90 - 200 °C 2: 75 percent / polyphosphoric acid / 1 h / 80 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 84, # 10 p. 1487 - 1503
反应条件
1: With AlCl3, aluminium chloride Under N2; 2: With bromine T=80°C; 0.0833333 h;
参考文献
US2003/232833 A1, ;
Page 12 ;
反应条件
carbon disulfide; aluminium trichloride T=0°C;
参考文献
Journal of the American Chemical Society, , vol. 60, p. 170,174
反应条件
1: 85 percent / AlCl3 / 1,2-dichloro-benzene / 7 h / 95 °C 2: 98 percent / KOH; H2NNH2 / triethylene glycol / 2 h / 200 °C 3: 95 percent / polyphosphoric acid / 2 h / 90 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 123, # 17 p. 3940 - 3952
反应条件
toluene-4-sulfonic acid in benzene T=105°C; 48 h;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2005/87714 A2, 2005 ;
Location in patent: Page/Page column 182-183 ;
WO 2005/087714 A2
反应条件
toluene-4-sulfonic acid in toluene Dean Stark;
参考文献
Zimmerman, Steven C.; VanZyl, Craig M.
Journal of the American Chemical Society, 1987 , vol. 109, # 25 p. 7894 - 7896
