2-(6-氨基嘌呤-9-基)-5-(羟基甲基)四氢呋喃-3,4-二醇合成路线 （共 9 条）
反应条件
ammonia in methanol T=20°C; 28 h;
参考文献
Henke, Christoph; Pfleiderer, Wolfgang
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 10-12 p. 1665 - 1706
反应条件
1: With 2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene T=80°C; Reduction; rearrangement; 0.25 h; 2: With potassium hydroxide in ethanol Hydrolysis; 1 h; Heating; Title compound not separated from byproducts;
参考文献
Gimisis, Thanasis; Ialongo, Giuseppina; Chatgilialoglu, Chryssostomos
Tetrahedron, 1998 , vol. 54, # 3-4 p. 573 - 592
反应条件
1: SnCl4 / acetonitrile / 18 h / 20 °C 2: 34 mg / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Bristow; Lythgoe
Journal of the Chemical Society, 1949 , p. 2306,2308
反应条件
1: Dowex 8x50W / 4.5 h / 20 °C 2: pyridine / 4 h / 20 °C 3: H2SO4 / acetic acid / 3 h / 20 °C 4: SnCl4 / acetonitrile / 18 h / 20 °C 5: 34 mg / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Patching, Simon G.; Baldwin, Stephen A.; Baldwin, Alexander D.; Young, James D.; Gallagher, Maurice P.; Henderson, Peter J. F.; Herbert, Richard B.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 462 - 470
反应条件
1: H2SO4 / acetic acid / 3 h / 20 °C 2: SnCl4 / acetonitrile / 18 h / 20 °C 3: 34 mg / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Patching, Simon G.; Baldwin, Stephen A.; Baldwin, Alexander D.; Young, James D.; Gallagher, Maurice P.; Henderson, Peter J. F.; Herbert, Richard B.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 462 - 470
反应条件
1: 1,2-dichloro-ethane / 0.25 h / 80 °C 2: 1.48 g / trimethylsilyl trifluorosulfonate; SnCl4 / acetonitrile / 20 h / 20 °C 3: 67 percent / NH3 / methanol / 28 h / 20 °C View Scheme
参考文献
Henke, Christoph; Pfleiderer, Wolfgang
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 10-12 p. 1665 - 1706
反应条件
1: 1.48 g / trimethylsilyl trifluorosulfonate; SnCl4 / acetonitrile / 20 h / 20 °C 2: 67 percent / NH3 / methanol / 28 h / 20 °C View Scheme
参考文献
Henke, Christoph; Pfleiderer, Wolfgang
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 10-12 p. 1665 - 1706
反应条件
sodium hydroxide; Pd-BaSO4 Hydrogenation;
参考文献
Bristow; Lythgoe
Journal of the Chemical Society, 1949 , p. 2306,2308
反应条件
1: palladium; acetic acid / Behandlung des Reaktionsprodukts mit Acetanhydrid und Pyridin 2: HBr / Erhitzen des Reaktionsprodukts mit dem Silber-Salz des 2,8-Dichlor-7(9)H-purin-6-ylamins in Xylol und Behandeln des Reaktionsprodukts mit methanol.NH3 3: aq. NaOH solution; palladium/BaSO4 / Hydrogenation View Scheme
参考文献
Bristow; Lythgoe
Journal of the Chemical Society, 1949 , p. 2306,2308
