(S)-4-(2-羟乙基)-2,2-二甲基-1,3-二氧戊环合成路线 （共 49 条）
反应条件
1: With ozone in methanol T=-78°C; 2: With sodium tetrahydroborate in methanol T=-78 - 20°C; Further stages.;
参考文献
Lebar, Matthew D.; Baker, Bill J.
Tetrahedron Letters, 2007 , vol. 48, # 45 p. 8009 - 8010
反应条件
sodium hydroxide in methanol 0.75 h; Ambient temperature;
参考文献
Boerjesson, Lena; Welch, Christopher J.
Tetrahedron, 1992 , vol. 48, # 30 p. 6325 - 6334
反应条件
1: With ozone in methanol T=-78°C; 2: With sodium tetrahydroborate in methanol T=-78 - 20°C; Further stages. Title compound not separated from byproducts.;
参考文献
Tetrahedron Letters, , vol. 48, # 45 p. 8009 - 8010
反应条件
1: 99 percent / pyridine / 12 h / Ambient temperature 2: 90 percent / LiCl / dimethylformamide / 12 h / 85 °C 3: 90 percent / H2, Et3N / palladium on carbon / methanol 4: 95 percent / LiAlH4 / diethyl ether / 1.) room temperature, 12 h, 2.) reflux, 1 h View Scheme
参考文献
Synthetic Communications, , vol. 19, # 17 p. 3077 - 3086
反应条件
1: 90 percent / LiCl / dimethylformamide / 12 h / 85 °C 2: 90 percent / H2, Et3N / palladium on carbon / methanol 3: 95 percent / LiAlH4 / diethyl ether / 1.) room temperature, 12 h, 2.) reflux, 1 h View Scheme
参考文献
Synthetic Communications, , vol. 19, # 17 p. 3077 - 3086
反应条件
1: 90 percent / H2, Et3N / palladium on carbon / methanol 2: 95 percent / LiAlH4 / diethyl ether / 1.) room temperature, 12 h, 2.) reflux, 1 h View Scheme
参考文献
Synthetic Communications, , vol. 19, # 17 p. 3077 - 3086
反应条件
1: (-)-(S)-hydroxybutanedioic acid With boric acid trimethyl ester; dimethylsulfide borane complex in tetrahydrofuran T=20°C; 24 h; 2: 2,2-dimethoxy-propane With camphor-10-sulfonic acid; copper(II) sulfate T=20°C; 16 h; Further stages.;
参考文献
Tetrahedron, , vol. 64, # 40 p. 9495 - 9506
反应条件
toluene-4-sulfonic acid
参考文献
Tetrahedron Letters, , vol. 26, # 9 p. 1185 - 1188
反应条件
1: 77 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 2: BF3*Et2O / diethyl ether / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 26 p. 5111 - 5123
反应条件
2: 83.8 percent / K2CO3 / methanol / 18 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 26 p. 5111 - 5123
