4-羟基-7-三氟甲基喹啉合成路线 （共 10 条）
反应条件
1: With potassium hydroxide in water; ethylene glycol T=200°C; P=12137.6 - 13171.9 Torr; 0.5 h; Irradiation; 2: With hydrogenchloride in water; ethylene glycol pH=6;
参考文献
PFIZER INC.
Patent: WO2005/63739 A1, 2005 ;
Location in patent: Page/Page column 45-46 ;
WO 2005/063739 A1
参考文献
Journal of the American Chemical Society, , vol. 69, p. 371,373
反应条件
1: diphenyl ether / Heating 2: 2 N NaOH / Heating 3: diphenyl ether / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 25 p. 4918 - 4926
反应条件
1: 100 percent / 1 h / 90 - 110 °C 2: diphenyl ether / Heating 3: 2 N NaOH / Heating 4: diphenyl ether / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 25 p. 4918 - 4926
反应条件
in diphenylether T=300°C; 0.0833333 h; microwave irradiation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1015 - 1018
反应条件
phosphorus pentachloride; trichlorophosphate T=130°C;
参考文献
Madrid, Peter B.; Sherrill, John; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1015 - 1018
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydroxide in tetrachloromethane T=60°C; 55 h;
参考文献
Giorgi-Renault, Sylviane; Renault, Jean; Bukovec, Zjelka
Synthesis, 1984 , # 6 p. 491 - 493
反应条件
phosphorus oxytribromide T=140°C; 4 h;
参考文献
Barlin, Gordon B.; Ireland, Stephen J.; Jiravinyu, Chuenjit; Nguyen, Trang M. T.; Kotecka, Barbara; Rieckmann, Karl H.
Australian Journal of Chemistry, 1993 , vol. 46, # 11 p. 1695 - 1704
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP96214 B1, 1991 ;
反应条件
1: POCl3 / 3 h / Heating
2: 2 h / 135 - 155 °C
View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
