8-甲氧基-1,2,3,4-四氢萘-2-甲酸合成路线 （共 15 条）
反应条件
hydrogen; palladium on activated charcoal in acetic acid T=70 - 80°C; P=760 Torr;
参考文献
Langlois; Gaudy
Synthetic Communications, 1992 , vol. 22, # 12 p. 1723 - 1734
反应条件
triethylsilane; trifluoroacetic acid T=20°C; 16 h;
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
ammonia; lithium; tert-butyl alcohol in tetrahydrofuran
参考文献
Mander, Lewis N.; Pyne, Stephen G.
Australian Journal of Chemistry, 1981 , vol. 34, # 9 p. 1899 - 1911
反应条件
1: 88 percent / acetic anhydride / 2 h / Heating 2: 54 percent / AlCl3 / nitrobenzene / 0.08 h 3: 96 percent / H2 / 10percent Pd/C / acetic acid / 70 - 80 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 54 percent / AlCl3 / nitrobenzene / 0.08 h 2: 96 percent / H2 / 10percent Pd/C / acetic acid / 70 - 80 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 86 percent / thionyl chloride, pyridine / toluene / Ambient temperature 2: 1.) Na, 3.) 2N NaOH 3: 88 percent / acetic anhydride / 2 h / Heating 4: 54 percent / AlCl3 / nitrobenzene / 0.08 h 5: 96 percent / H2 / 10percent Pd/C / acetic acid / 70 - 80 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 1.) Na, 3.) 2N NaOH 2: 88 percent / acetic anhydride / 2 h / Heating 3: 54 percent / AlCl3 / nitrobenzene / 0.08 h 4: 96 percent / H2 / 10percent Pd/C / acetic acid / 70 - 80 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 47 percent / Na / ethanol / 2 h / Heating 2: 87.6 percent / H2 / 10percent Pd/C / acetic acid 3: 88 percent / acetic anhydride / 2 h / Heating 4: 54 percent / AlCl3 / nitrobenzene / 0.08 h 5: 96 percent / H2 / 10percent Pd/C / acetic acid / 70 - 80 °C / 760 Torr View Scheme
参考文献
Synthetic Communications, , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 1.) butyllithium, tetramethylenediamine / 1.) THF, hexane, 25 deg C, 20 h, 2.) THF, hexane, -20 deg C 2: 95 percent / Li, liq. NH3, t-butyl alcohol / tetrahydrofuran View Scheme
参考文献
Australian Journal of Chemistry, , vol. 34, # 9 p. 1899 - 1911
反应条件
1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 5 h / 20 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C 3: AlCl3, aluminium chloride / chloroform / 0.5 h / 0 °C 4: sodium tetrahydroborate; sodium hydroxide / water / 72 h / 20 °C 5: triethylsilane; trifluoroacetic acid / 16 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 3 p. 1299 - 1307
