N-(2-苯基乙基)羟胺合成路线 （共 14 条）
反应条件
triethylsilane; palladium diacetate in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Rahaim Jr., Ronald J.; Maleczka Jr., Robert E.
Synthesis, 2006 , # 19 p. 3316 - 3340
反应条件
triethylsilane; potassium fluoride; palladium diacetate in tetrahydrofuran; water T=20°C;
参考文献
Rahaim Jr., Ronald J.; Maleczka Jr., Robert E.
Synthesis, 2006 , # 19 p. 3316 - 3340
反应条件
hydrogenchloride; sodium cyanoborohydride in tetrahydrofuran; methanol T=20°C; 0.5 h;
参考文献
Lin, Jing; Cashman, John R.
Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 282, # 3 p. 1269 - 1279
反应条件
hydroxylamine in water; isopropyl alcohol T=140°C; intermolecular Cope-type hydroamination; 72 h;
参考文献
Beauchemin, Andre M.; Moran, Joseph; Lebrun, Marie-Eve; Seguin, Catherine; Dimitrijevic, Elena; Zhang, Lili; Gorelsky, Serge I.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 8 p. 1410 - 1413
反应条件
hydroxylamine in water; isopropyl alcohol T=140°C; Cope-type hydroamination; Inert atmosphere; regioselective reaction;
参考文献
Moran, Joseph; Gorelsky, Serge I.; Dimitrijevic, Elena; Lebrun, Marie-Eve; Bedard, Anne-Catherine; Seguin, Catherine; Beauchemin, Andre M.
Journal of the American Chemical Society, 2008 , vol. 130, # 52 p. 17893 - 17906
参考文献
SmithKline Corporation
Patent: US4171359 A1, 1979 ;
反应条件
sodium tetrahydroborate; borane-THF in tetrahydrofuran 1 h;
参考文献
Kabalka, George W.; Laila Guindi; Varma, Rajender S.
Tetrahedron, 1990 , vol. 46, # 21 p. 7443 - 7457
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Mourad, M. Soubei; Varma, Rajender S.; Kabalka, George W.
Journal of Organic Chemistry, 1985 , vol. 50, # 1 p. 133 - 135
反应条件
hydroxylamine hydrochloride in methanol T=60°C; Substitution; Hydroxylaminolysis; 2 h;
参考文献
Tokuyama; Kuboyama; Amano; Yamashita; Fukuyama
Synthesis, 2000 , # 9 p. 1299 - 1304
反应条件
(i) PhCHO, MgSO4, (ii) MCPBA, (iii) aq. H2SO4; Multistep reaction;
参考文献
Tokuyama; Kuboyama; Amano; Yamashita; Fukuyama
Synthesis, 2000 , # 9 p. 1299 - 1304
参考文献
SmithKline Corporation
Patent: US4255422 A1, 1981 ;
US 4255422 A
