7-氟-2H-3,1-苯并噁嗪-2,4-二酮合成路线 （共 12 条）
反应条件
in tetrahydrofuran T=0 - 50°C; 6 h;
参考文献
MERCK SHARP and DOHME CORP.; REGER, Thomas; WALJI, Abbas M.; SANDERS, John M.; WAI, John S.; HU, Lihong; FANG, Shunda; WANG, Liping; YANG, Pengyu; MA, Zonghui; SUN, Liansheng
Patent: WO2014/8636 A1, 2014 ;
Location in patent: Page/Page column 35 ;
反应条件
Oxonereg; in water; acetonitrile T=40°C; 1 h;
参考文献
Nelson, Amber C.; Kalinowski, Emily S.; Czerniecki, Nikolas J.; Jacobson, Taylor L.; Grundt, Peter
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 43 p. 7455 - 7457
反应条件
sulfuric acid; dihydrogen peroxide in water; acetic acid T=60 - 70°C; 2 h;
参考文献
Reissenweber, Gernot; Mangold, Dietrich
Angewandte Chemie, 1980 , vol. 92, # 3 p. 196 - 197
反应条件
in 1,4-dioxane 11 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 5 p. 1172 - 1188
反应条件
1: pyridine / 24 h / Heating 2: acetic acid / 24 h 3: lithium aluminum hydride / tetrahydrofuran / 24 h View Scheme
参考文献
Sabb, Annmarie L.; Vogel, Robert L.; Welmaker, Gregory S.; Sabalski, Joan E.; Coupet, Joseph; Dunlop, John; Rosenzweig-Lipson, Sharon; Harrison, Boyd
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2603 - 2607
反应条件
1: 1.) sodium hydride / 1) toluene, 70 - 75 deg C, 1 h; 2) touene, 30 deg C, 20 min 2: glacial acetic acid / ethanol / Heating 3: 1.) potassium hydroxide / 1) water, 50 deg C, 50 deg C, 20 min; 2) water, room temperature View Scheme
参考文献
Birch, Alan M.; Davies, Roy V.; Maclean, Lachlan; Robinson, Keith
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 387 - 392
反应条件
ammonia; triethylamine in tetrahydrofuran; water 2.5 h;
参考文献
Synthesis (Germany), , vol. 45, # 21 art. no. SS-2013-H0422-OP, p. 2998 - 3006
反应条件
1: triethylamine; ammonia / tetrahydrofuran; water / 2.5 h 2: toluene-4-sulfonic acid / tetrahydrofuran / 0.17 h / 20 °C 3: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Cheng, Ran; Guo, Tianjian; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang
Synthesis (Germany), 2013 , vol. 45, # 21 art. no. SS-2013-H0422-OP, p. 2998 - 3006
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
参考文献
Allison, Brett; McAtee, Laura C.; Phuong, Victor K.; Rabinowitz, Michael H.; Shankley, Nigel P.
Patent: US2004/224983 A1, 2004 ;
Location in patent: Page 28 ;
