2-氟-4-甲氧基苯甲酰氯合成路线 （共 8 条）
反应条件
sulfuryl dichloride RefluxInert atmosphere;
参考文献
JOHANN WOLFGANG GOETHE-UNIVERSITÄT; GENKYOTEX SA; BRANDES, Ralf; SCHRÖDER, Katrin; PAGE, Patrick; LALEU, Benoît; GAGGINI, Francesca
Patent: WO2013/68972 A1, 2013 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 66 percent / Br2, NaOH / H2O / 2 h / Ambient temperature 2: 89 percent / SOCl2 / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 323, # 2 p. 73 - 78
反应条件
1: 61 percent / bromine / CHCl3 / 0.01 h 2: 1-methyl-2-pyrrolidinone / 2 h / 180 °C 3: sodium hydroxide / H2O / 60 h 4: 62 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating 5: thionyl chloride / 1.5 h / Heating View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 67, p. 1 - 24
反应条件
1: 1-methyl-2-pyrrolidinone / 2 h / 180 °C 2: sodium hydroxide / H2O / 60 h 3: 62 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating 4: thionyl chloride / 1.5 h / Heating View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 67, p. 1 - 24
反应条件
1: sodium hydroxide / H2O / 60 h 2: 62 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating 3: thionyl chloride / 1.5 h / Heating View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 67, p. 1 - 24
反应条件
1: 62 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating 2: thionyl chloride / 1.5 h / Heating View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 67, p. 1 - 24
反应条件
lithium aluminium tetrahydride; diethyl ether Erwaermen des Reaktionsprodukts mit SOCl2;
参考文献
Journal of the American Chemical Society, , vol. 72, p. 1806
反应条件
1: LiAlH4; diethyl ether / Erwaermen des Reaktionsprodukts mit SOCl2 3: aqueous NaOH / anschliessend Erwaermen mit wss. HCl 4: aqueous HBr View Scheme
参考文献
Bennett; Niemann
Journal of the American Chemical Society, 1950 , vol. 72, p. 1806
