1: sulfuric acid / 120 h / Reflux
2: potassium carbonate / acetone / Reflux
3: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C
View Scheme
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1
1: 97 percent / LiAlH4 / diethyl ether / 0.75 h / Heating
2: 97 percent / pyridine / 2 h / 25 °C
View Scheme
参考文献
Kemp, D. S.; Carey, Robert I.; Dewan, John C.; Galakatos, Nicholas G.; Kerkman, Daniel; Leung, See-Lap
Journal of Organic Chemistry, 1989 , vol. 54, # 7 p. 1589 - 1603