5-甲基-3-异噁唑羧酸乙酯合成路线 （共 26 条）
反应条件
hydrazine hydrate in ethanol 6 h; Heating;
参考文献
Sung; Lee
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1101 - 1109
反应条件
1: 80 percent / NaBH4 / ethanol / 1). 0 deg C, 2). room temp., 3 h. 2: 52 percent / pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Baraldi, P. G.; Simoni, D.; Moroder, F.; Manfredini, S.; Mucchi, L.; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 557 - 560
反应条件
1: 60 percent / LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C 2: 65 percent / Ph3PBr2 / CH2Cl2 / 1 h / Ambient temperature 3: 84 percent / NaN3 / acetone / 24 h / Ambient temperature View Scheme
参考文献
Pei; Wickhan
Tetrahedron Letters, 1993 , vol. 34, # 47 p. 7509 - 7512
反应条件
1: 60 percent / LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C 2: 65 percent / Ph3PBr2 / CH2Cl2 / 1 h / Ambient temperature 3: 84 percent / NaN3 / acetone / 24 h / Ambient temperature 4: 98 percent / NaBH4, TEA / HS(CH2)3SH / propan-2-ol / 24 h / Ambient temperature View Scheme
参考文献
Pei; Wickhan
Tetrahedron Letters, 1993 , vol. 34, # 47 p. 7509 - 7512
反应条件
1: 60 percent / LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C 2: 65 percent / Ph3PBr2 / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Cherton, Jean-Claude; Lanson, Marc; Ladjama, Daif; Guichon, Yvette; Basselier, Jean-Jacques
Canadian Journal of Chemistry, 1990 , vol. 68, # 8 p. 1271 - 1276
反应条件
1: 34 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 4 h / 95 °C
2: K2CO3 / dimethylformamide / 1 h / 60 °C
View Scheme
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
1: 34 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 4 h / 95 °C
2: K2CO3 / dimethylformamide / 1 h / 60 °C
View Scheme
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
1: 34 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 4 h / 95 °C
2: K2CO3 / dimethylformamide / 1 h / 60 °C
View Scheme
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
1: 34 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 4 h / 95 °C
2: K2CO3 / dimethylformamide / 1 h / 60 °C
View Scheme
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
1: 34 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 4 h / 95 °C
2: K2CO3 / dimethylformamide / 1 h / 60 °C
View Scheme
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
