5-甲基-3-异噁唑羧酸乙酯合成路线 （共 26 条）
反应条件
hydroxylamine hydrochloride in ethanol 3 h; Heating;
参考文献
Baraldi, P. G.; Simoni, D.; Moroder, F.; Manfredini, S.; Mucchi, L.; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 557 - 560
反应条件
hydroxylamine hydrochloride; sodium carbonate in methanol; water T=0°C; 2 h;
参考文献
Mitani, Michiharu; Tanaka, Yasunori; Sawada, Akihiko; Misu, Ayuko; Matsumoto, Yoshihiro
European Journal of Organic Chemistry, 2008 , # 8 p. 1383 - 1391
反应条件
hydroxylammonium sulfate in ethanol; toluene
反应条件
hydroxylamine hydrochloride; sodium hydrogencarbonate in ethanol 4 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
European Journal of Medicinal Chemistry, , vol. 27, # 6 p. 581 - 593
反应条件
triethylamine in diethyl ether 2 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2441 - 2445
反应条件
ammonium hydroxide in ethanol T=0°C; 72 h;
参考文献
Good,R.H. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 2441 - 2445
反应条件
sodium tetrahydroborate in ethanol
参考文献
Masciadri, Raffaello; Thomas, Andrew William; Wichmann, Juergen
Patent: US2003/55042 A1, 2003 ;
参考文献
Beecham Group p.l.c.
Patent: US4812470 A1, 1989 ;
反应条件
lithium hydroxide in tetrahydrofuran 0.333333 h; Heating;
参考文献
TARGEGEN, INC.
Patent: WO2008/8234 A1, 2008 ;
Location in patent: Page/Page column 103-104 ;
反应条件
1: aq. NH3 / ethanol / 72 h / 0 °C 2: P2O5 / 160 °C View Scheme
参考文献
Good,R.H. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 2441 - 2445
