4-(3-甲氧基苯基)吗啉合成路线 （共 24 条）
反应条件
sodium t-butanolate; palladium diacetate in toluene T=80°C; Buchwald-Hartwig amination; 0.5 h;
参考文献
Reddy, Ch. Venkat; Kingston, Jesudoss V.; Verkade, John G.
Journal of Organic Chemistry, 2008 , vol. 73, # 8 p. 3047 - 3062
反应条件
caesium carbonate; P(i-BuNCH2)3CMe; palladium diacetate in toluene T=80°C; Buchwald-Hartwig amination reaction;
参考文献
Iowa State University Research Foundation, Inc.
Patent: US7385058 B1, 2008 ;
Location in patent: Page/Page column 31-34; 35-36 ;
反应条件
PdCl2(C3H3N2(CH3))(C3H2N2(C6H3(C3H7)2)2); potassium tert-butylate in 1,4-dioxane T=70°C; 3 h; Inert atmosphere;
参考文献
Zhu, Lei; Gao, Ting-Ting; Shao, Li-Xiong
Tetrahedron, 2011 , vol. 67, # 29 p. 5150 - 5155
反应条件
copper acetylacetonate; oxygen; benzoic acid in acetonitrile T=50°C; 12 h;
参考文献
Zhou, Yanping; Xie, Yinjun; Yang, Lei; Xie, Pan; Huang, Hanmin
Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2713 - 2716
反应条件
sodium t-butanolate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride; chlorobis(triphenylphosphine)(1-naphthyl)nickel(II) in 1,4-dioxane T=110°C; 0.25 h;
参考文献
Gao, Cai-Yan; Yang, Lian-Ming
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1624 - 1627
反应条件
N-ethyl-N,N-diisopropylamine in toluene Heating;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1847535 A1, 2007 ;
Location in patent: Page/Page column 78-79 ;
EP 1847535 A1
反应条件
NiCl(1-naphthyl)(PPh3)2; sodium hydride; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride in 1,4-dioxane T=110°C; Inert atmosphere;
参考文献
Huang, Jin-Hua; Yang, Lian-Ming
Organic Letters, 2011 , vol. 13, # 14 p. 3750 - 3753
反应条件
NHC-Pd(II)-Im; potassium tert-butylate in tetrahydrofuran T=20°C; 6 h; Inert atmosphere;
参考文献
Chen, Wen-Xin; Shao, Li-Xiong
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9236 - 9239,4
Title/Abstract Full Text Show Details
Chen, Wen-Xin; Shao, Li-Xiong
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9236 - 9239
反应条件
potassium tert-butylate in dimethyl sulfoxide 0.166667 h; Heatingmicrowave irradiation;
参考文献
Shi, Lei; Wang, Min; Fan, Chun-An; Zhang, Fu-Min; Tu, Yong-Qiang
Organic Letters, 2003 , vol. 5, # 19 p. 3515 - 3517
参考文献
Halbrook, James; Kesicki, Edward A.; Burgess, Laurence E.; Schlachter, Stephen T.; Eary, Charles T.; Schiro, Justin G; Huang, Hongmei; Evans, Michael; Han, Yongxin
Patent: US2002/165218 A1, 2002 ;
US 20020165218 A1
