in water; acetone T=5°C; Reflux;

1.1: 1 h / 130 °C / Neat (no solvent) 2.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 2.2: 0 °C / pH 1 3.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 3.2: 90 °C 4.1: water; acetone / 5 °C / Reflux View Scheme

1.1: potassium hydroxide / ethanol / Reflux 2.1: 1 h / 130 °C / Neat (no solvent) 3.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 3.2: 0 °C / pH 1 4.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 4.2: 90 °C 5.1: water; acetone / 5 °C / Reflux View Scheme

1.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 1.2: 0 °C / pH 1 2.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 2.2: 90 °C 3.1: water; acetone / 5 °C / Reflux View Scheme

1.1: sodium ethanolate / 2 h / 20 °C 1.2: 28 h / 20 - 78 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 40 °C 2.2: 3 h / 80 °C 3.1: potassium hydroxide / ethanol / Reflux 4.1: 1 h / 130 °C / Neat (no solvent) 5.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 5.2: 0 °C / pH 1 6.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 6.2: 90 °C 7.1: water; acetone / 5 °C / Reflux View Scheme

1.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 1.2: 90 °C 2.1: water; acetone / 5 °C / Reflux View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide / 40 °C 1.2: 3 h / 80 °C 2.1: potassium hydroxide / ethanol / Reflux 3.1: 1 h / 130 °C / Neat (no solvent) 4.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 4.2: 0 °C / pH 1 5.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 5.2: 90 °C 6.1: water; acetone / 5 °C / Reflux View Scheme

1.1: pyridine / 3 h / 0 °C 2.1: sodium ethanolate / 2 h / 20 °C 2.2: 28 h / 20 - 78 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C 3.2: 3 h / 80 °C 4.1: potassium hydroxide / ethanol / Reflux 5.1: 1 h / 130 °C / Neat (no solvent) 6.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 6.2: 0 °C / pH 1 7.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 7.2: 90 °C 8.1: water; acetone / 5 °C / Reflux View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide / 40 °C 1.2: 3 h / 80 °C 2.1: potassium hydroxide / ethanol / Reflux 3.1: 1 h / 130 °C / Neat (no solvent) 4.1: (S)-1-phenyl-ethylamine / diethyl ether / 1 h / 20 °C 4.2: 0 °C / pH 1 5.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 5.2: 90 °C 6.1: water; acetone / 5 °C / Reflux View Scheme

1.1: 1 h / 130 °C / Neat (no solvent) 2.1: (R)-1-phenyl-ethyl-amine / diethyl ether / 1 h / 20 °C 2.2: 0 °C / pH 1 3.1: potassium carbonate / water; toluene / 0.5 h / 20 °C 3.2: 90 °C 4.1: water; acetone / 5 °C / Reflux View Scheme