1: With trifluorormethanesulfonic acid in acetonitrile T=55°C; 12.5 h; Industry scale; 2: With methanol; sodium methylate in dimethyl sulfoxide; acetonitrile T=22 - 23°C; 3.75 h;

1: 5-aza-cytosine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane in acetonitrile 20 h; Heating / reflux; 2: (2R,3R,4R,5S)-4,5-bis(acetyloxy)-2-[(acetyloxy)methyl]tetrahydro-3-furanyl acetate With trimethylsilyl trifluoromethanesulfonate in acetonitrile T=20°C; 20 h; 3: With sodium methylate; sodium hydrogencarbonate more than 3 stages;

methanol; sodium methylate T=20 - 25°C; 1.58333 h; Product distribution / selectivity;

1: 5-aza-cytosine With N,O-bis(trimethylsilyl) trifluoroacetamide in dichloromethane 1.5 h; Reflux; 2: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose With trimethylsilyl trifluoromethanesulfonate in dichloromethane 2.16667 h; Reflux; 3: With methanol; sodium methylate T=50°C; 1 h;

1: 5-aza-cytosine With N,O-bis(trimethylsilyl) trifluoroacetamide in dichloromethane 1.5 h; Reflux; 2: 1,2,3,5-tetra-O-acetyl-D-ribofuranose With trimethylsilyl trifluoromethanesulfonate in dichloromethane 2.16667 h; Reflux; 3: With methanol; sodium methylate T=50°C; 1 h; Product distribution / selectivity;

tin(IV) chloride in dichloromethane; dimethyl sulfoxide

N-butylamine in methanol T=65°C; 1 h;

1: With tin(IV) chloride in 1,2-dichloro-ethane T=5 - 20°C; 2.25 h; 2: With water; sodium hydrogencarbonate in 1,2-dichloro-ethane T=15 - 20°C; 0.5 h; Product distribution / selectivity;

T=37°C; pH 9.5; other temperature, pH; decomposition of 5-aza-2'-deoxycytidine and 5-azacytidine on alkali and neutral solutions, HPLC study; Rate constant;

in acetone 24 h; Inert atmosphere;