2-氯-5-氨基三氟甲苯合成路线 （共 49 条）
反应条件
potassium tert-butylate; sodium chloride in methanol; hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
BAYER CORPORATION
Patent: US2003/216396 A1, 2003 ;
US 20030216396 A1
反应条件
sodium hydrogensulfide; sodium hydrogencarbonate in methanol; water 1 h; Heating;
参考文献
Yazdanbakhsh, Mohammad R.; Mahmoodi, Nosrat O.; Dabiry, Shahram
Mendeleev Communications, 2006 , # 3 p. 192 - 194
反应条件
copper dichloride; [C6MIm][Cl] T=40°C; 8 h; regioselective reaction;
参考文献
Wang, Han; Wen, Kun; Nurahmat, Nurbiya; Shao, Yan; Zhang, He; Wei, Chao; Li, Ya; Shen, Yongjia; Sun, Zhihua
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 744 - 748
反应条件
dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate in 1,4-dioxane T=100°C; 24 h; Inert atmosphere; Overall yield = 72 percent; Overall yield = 140.9 mg;
参考文献
Organic Letters, , vol. 15, # 14 p. 3734 - 3737
反应条件
1: 60 percent / HNO3; H2SO4 / 0.5 h / 50 - 60 °C 2: 65 percent / NaSH*9H2O; NaHCO3 / methanol; H2O / 1 h / Heating View Scheme
参考文献
Mendeleev Communications, , # 3 p. 192 - 194
反应条件
sodium hydroxide in ethanol; water T=83°C; 24 h; Irradiationfurther reagents, further conditions;
参考文献
Acta Chimica Hungarica, , vol. 124, # 4 p. 603 - 608
参考文献
El-Sharief, Ahmed M. Sh.; Moussa, Ziad
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4315 - 4334
反应条件
in 1,4-dioxane T=55°C; Inert atmosphere;
参考文献
Denoyelle, Severine; Chen, Ting; Chen, Limo; Wang, Yibo; Klosi, Edvin; Halperin, Jose A.; Aktas, Bertal H.; Chorev, Michael
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 402 - 409
反应条件
sodium carbonate; chlorobenzene
参考文献
Geigy A. G.
Patent: DE1003717 , 1954 ;
参考文献
Geigy A. G.
Patent: DE1003717 , 1954 ;
