5-甲氧基-2,3-二氢-1H-茚-1-醇合成路线 （共 8 条）
反应条件
sodium tetrahydroborate in ethanol
参考文献
Fournier; Berthelot; Pavard; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 1 p. 48 - 58
反应条件
1: polyphosphoric acid 2: LiAlH4 / diethyl ether View Scheme
参考文献
Hofer,O.
Monatshefte fuer Chemie, 1978 , vol. 109, p. 405 - 419
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 55 °C / Inert atmosphere 2: chromium(VI) oxide; acetic acid / water / 4.5 h / 20 °C / Cooling with ice 3: sodium tetrahydroborate; methanol / 2 h / Reflux View Scheme
参考文献
Abbott Laboratories; Abbott GmbH and Co. KG
Patent: US2012/40948 A1, 2012 ;
US 20120040948 A1
反应条件
1: chromium(VI) oxide; acetic acid / water / 4.5 h / 20 °C / Cooling with ice 2: sodium tetrahydroborate; methanol / 2 h / Reflux View Scheme
参考文献
Abbott Laboratories; Abbott GmbH and Co. KG
Patent: US2012/40948 A1, 2012 ;
US 20120040948 A1
反应条件
water in acetone T=21.2°C; other temp.; Rate constantKinetics;
参考文献
Friedrich, Edwin C.; Tam, Teresa M.
Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 315 - 319
反应条件
1: 6.8 g / p-toluenesulfonic acid monohydrate / tetrahydrofuran / 1 h / Heating 2: N-bromoacetamide / tetrahydrofuran; H2O / 0.5 h / 20 °C 3: 90 percent / KOH / tetrahydrofuran / 1 h / 20 °C 4: NaClO4; H2O / dioxane / 0.08 h / 20 °C / pH 7.23 View Scheme
参考文献
Abbott Laboratories; Abbott GmbH and Co. KG
Patent: US2012/40948 A1, 2012 ;
US 20120040948 A1
反应条件
hydrogenchloride; acetic acid Heating;
参考文献
Abbott Laboratories; Abbott GmbH and Co. KG
Patent: US2012/40948 A1, 2012 ;
Location in patent: Page/Page column 96-97 ;
US 20120040948 A1
反应条件
palladium dichloride in methanol
T=40°C; 18 h; Inert atmosphereGreen chemistry; chemoselective reaction;
参考文献
Wang, Hu; Li, Li; Bai, Xing-Feng; Shang, Jun-Yan; Yang, Ke-Fang; Xu, Li-Wen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 341 - 347
