3-吡咯烷-1-甲酸苄酯合成路线 （共 23 条）
反应条件
in dichloromethane T=0°C; 14 h;
参考文献
WYETH
Patent: US2006/189616 A1, 2006 ;
Location in patent: Page/Page column 13; 19 ;
US 20060189616 A1
反应条件
PQS-attached Grubbs-Hoveyda-1 metathesis catalyst in water T=20°C; 3 h; Micellar solution;
参考文献
Lipshutz, Bruce H.; Ghorai, Subir
Organic Letters, 2009 , vol. 11, # 3 p. 705 - 708
反应条件
in 1,4-dioxane T=20°C; 18 h;
参考文献
ABRAMS, Tinya; BARSANTI, Paul A.; DING, Yu; DUHL, David; HAN, Wooseok; HU, Cheng; PAN, Yue
Patent: US2011/256128 A1, 2011 ;
Location in patent: Page/Page column 14; 22 ;
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene; Xtalfluor-E® in dichloromethane T=-78 - 20°C; 24.5 h; Inert atmosphere; 2: With water; sodium hydrogencarbonate in dichloromethane T=20°C; 0.25 h;
参考文献
OMEGACHEM INC.; COUTURIER, Michel; L'HEUREUX, Alexandre
Patent: WO2010/145037 A1, 2010 ;
Location in patent: Page/Page column 48-49 ;
反应条件
1: 2,5-dihydro-1H-pyrrole hydrochloride With potassium carbonate in water; ethyl acetate T=20°C; 0.5 h; 2: benzyl chloroformate in water; ethyl acetate T=0°C; 1 h;
参考文献
WO2010/114971 A1, ;
Page/Page column 148-149 ;
反应条件
in 1,4-dioxane; H2 O.Na2 CO3; hexane; ethyl acetate
参考文献
Abbott Laboratories
Patent: US5703244 A1, 1997 ;
反应条件
triethylamine tris(hydrogen fluoride); Xtalfluor-E® in dichloromethane T=20°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 11, # 21 p. 5050 - 5053
反应条件
potassium hydrogencarbonate in chloroform T=20°C;
参考文献
Maruyama, Keisuke; Noguchi-Yachide, Tomomi; Sugita, Kazuyuki; Hashimoto, Yuichi; Ishikawa, Minoru
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6661 - 6666
反应条件
in 1,4-dioxane T=20°C; 18 h;
参考文献
WO2011/26917 A1, ;
Page/Page column 72 ;
WO 2011/026917 A1
反应条件
in dichloromethane Ambient temperature;
参考文献
Rosenberg, Saul H.; Woods, Keith W.; Sham, Hing L.; Kleinert, Hollis D.; Martin, Donald L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1962 - 1969
