5-(N-邻苯二甲酰亚氨基)-2-戊酮合成路线 （共 11 条）
反应条件
1: With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20 - 80°C; 18 - 24 h; 2: With water in DMF (N,N-dimethyl-formamide) T=0 - 5°C; 1 h;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/93239 A2, 2003 ;
Location in patent: Page/Page column 7 ;
反应条件
in N,N-dimethyl-formamide T=80°C;
参考文献
Zyryanov, Grigory V.; Kinstle, Thomas H.; Anzenbacher Jr., Pavel
Synlett, 2008 , # 8 p. 1171 - 1174
反应条件
hydrogenchloride in acetone
参考文献
ELI LILLY AND COMPANY
Patent: EP835869 A2, 1998 ;
反应条件
sodium hydroxide in n-heptane; water; N,N-dimethyl-formamide
反应条件
1: With hydrogen fluoride T=0°C; 5 h; 2: With sodium carbonate cooling; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 73, # 7 p. 2875 - 2878
反应条件
hydrogenchloride; ethanol; water
参考文献
Journal of Organic Chemistry, , vol. 17, p. 149,153
反应条件
bromine; urea in methanol 24 h;
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
反应条件
bromine; urea in methanol T=20°C; 24 h;
参考文献
Geyer, Roland; Kaske, Melanie; Baumeister, Paul; Buschauer, Armin
Archiv der Pharmazie, 2014 , vol. 347, # 2 p. 77 - 88
反应条件
1: 63.5 percent / Br2 / CCl4 / 3 h / Ambient temperature 2: 55.3 percent / dimethylformamide / 3 h / 120 °C 3: 75.2 percent / 30percent aq. HBr / 5 h / Heating View Scheme
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
反应条件
1: Br2 / methanol; butan-1-ol; dioxane / 50 - 55 °C
2: NH3 (liquid) / 1.) 24 h, 13-14 bar, 35-37 deg C, 2.) 9 h, 18-20 bar, 48-50 deg C
3: 1.) 6N NaOH, 2.) 6N HCl / 1.) water, 2 h, reflux, 2.) ethanol, reflux, 3.) water, reflux
View Scheme
参考文献
Elz, Sigurd; Schunack, Walter
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 2 p. 238 - 242
