4-(1,1-二甲基乙基)-3-硝基苯胺合成路线 （共 12 条）
反应条件
sodium sulfide; sulfur
参考文献
Atwal, Karnail S.; Ferrara, Francis N.; Ding, Charles Z.; Grover, Gary J.; Sleph, Paul G.; Dzwonczyk, Steven; Baird, Anne J.; Normandin, Diane E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 304 - 313
反应条件
KNO3 in sulfuric acid
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 92 percent / H2SO4; HNO3 / H2O / 0 - 20 °C 2: H2 / Pd/C / ethyl acetate View Scheme
参考文献
Murphy, J. Timothy; Ridd, John H.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 1767 - 1772
反应条件
sodium hydroxide; bromine
参考文献
Stork; White
Journal of the American Chemical Society, 1956 , vol. 78, p. 4604,4608
反应条件
1: nitric acid / 60 °C 2: alcohol; hydrogen sulfide; ammonia View Scheme
参考文献
Shoesmith; Mackie
Journal of the Chemical Society, 1928 , p. 2336
反应条件
1: (i) (decarboxylation), (ii) (nitration) 2: aq. Na2S2 View Scheme
参考文献
Lesslie,M.S.; Mayer,U.J.H.
Journal of the Chemical Society, 1961 , p. 611 - 618
参考文献
Shoesmith; Mackie
Journal of the Chemical Society, 1928 , p. 2336
反应条件
Diazotization.anschliessende Behandlung mit Hypophosphorigsaeure;
参考文献
Stegmann,H.B. et al.
Chemische Berichte, 1976 , vol. 109, p. 2243 - 2258
反应条件
1: absolute-alcoholic sulfuric acid / Diazotization 2: iron; acetic acid / 90 °C View Scheme
参考文献
Lesslie,M.S.; Mayer,U.J.H.
Journal of the Chemical Society, 1961 , p. 611 - 618
参考文献
Shoesmith; Mackie
Journal of the Chemical Society, 1928 , p. 2336
