2-氨基-4-硝基苯甲酰胺合成路线 (共 9 条)
反应条件
1: With thionyl chloride T=60°C; 3 h; 2: With ammonium hydroxide T=20°C;
参考文献
Plemper, Richard K.; Doyle, Joshua; Sun, Aiming; Prussia, Andrew; Cheng, Li-Ting; Rota, Paul A.; Liotta, Dennis C.; Snyder, James P.; Compans, Richard W.
Antimicrobial Agents and Chemotherapy, 2005 , vol. 49, # 9 p. 3755 - 3761
反应条件
ammonia in 1,4-dioxane Substitution; 2 h;
参考文献
Rampa, Angela; Bisi, Alessandra; Belluti, Federica; Gobbi, Silvia; Valenti, Piero; Andrisano, Vincenza; Cavrini, Vanni; Cavalli, Andrea; Recanatini, Maurizio
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 497 - 506
反应条件
copper(l) iodide; sodium azide; ethanol; caesium carbonate; N-methyl-2-(methylamino)ethylamine T=20 - 95°C; Inert atmosphereSealed tube;
参考文献
Zhao, Haibo; Fu, Hua; Qiao, Renzhong
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3311 - 3316
反应条件
titanium(III) chloride in methanol; water Title compound not separated from byproducts;
参考文献
Russian Journal of General Chemistry, , vol. 76, # 1 p. 76 - 81
反应条件
phosphorus pentoxide in toluene Dehydration; 15 h; Heating;
参考文献
Rampa, Angela; Bisi, Alessandra; Belluti, Federica; Gobbi, Silvia; Valenti, Piero; Andrisano, Vincenza; Cavrini, Vanni; Cavalli, Andrea; Recanatini, Maurizio
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 497 - 506
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
参考文献
Amgen Inc.
Patent: US2003/225106 A1, 2003 ;
Location in patent: Page 86 ;
反应条件
1: 12 N HCl / 20 °C 2: SOCl2 / dimethylformamide / Heating View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Matsumoto, Mitsuhiro; Obara, Fumihiro; Nagasaki, Takahiro; Hayashi, Hideya
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 545 - 548
反应条件
borane-THF in tetrahydrofuran
2 h; Reflux;
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP2128157 A1, 2009 ;
Location in patent: Page/Page column 102 ;
EP 2128157 A1