1: water; tetrahydrofuran 2: hydrogenchloride; water 3: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water 4: acetic acid 5: sodium nitrite 6: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol View Scheme

1: water; tetrahydrofuran 2: hydrogenchloride; water 3: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water 4: acetic acid 5: sodium nitrite 6: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol 7: hydrogenchloride; sodium hydroxide; dihydrogen peroxide / ethyl acetate; toluene; water; isopropylmagnesium chloride; tetrahydrofuran View Scheme

in tetrahydrofuran T=20°C;